cis-1-hydroxy-4-isopropenylcyclohexanecarbonitrile

Base Information

• Chemical Name: cis-1-hydroxy-4-isopropenylcyclohexanecarbonitrile
• CAS No.: 461685-59-6
• Molecular Formula: C₁₀H₁₅NO
• Molecular Weight: 165.235
• Mol file: 461685-59-6.mol

Synonyms:cis-1-hydroxy-4-isopropenylcyclohexanecarbonitrile

Chemical Property of cis-1-hydroxy-4-isopropenylcyclohexanecarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of cis-1-hydroxy-4-isopropenylcyclohexanecarbonitrile

There total 3 articles about cis-1-hydroxy-4-isopropenylcyclohexanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

hydrogen isocyanide (74-90-8,6914-07-4) + 4-isopropenylcyclohexanone (22460-53-3) → cis-1-hydroxy-4-isopropenylcyclohexanecarbonitrile (461685-59-6) + trans-1-hydroxy-4-isopropenylcyclohexanecarbonitrile

Guidance literature:

With hydrogen cyanide; (S)-Me-hydroxynitrile lyase; nitrocellulose; In di-isopropyl ether; at 20 ℃; for 5h;

DOI:10.1002/chem.200401147

Reference yield:

hydrogen cyanide (74-90-8) + 4-isopropenylcyclohexanone (22460-53-3) → cis-1-hydroxy-4-isopropenylcyclohexanecarbonitrile (461685-59-6)

Guidance literature:

With hydroxynitrile lyase from cassava (Manihot esculenta); In di-isopropyl ether; at 20 ℃; for 9h; Enzymatic reaction;

DOI:10.1139/v02-087

Reference yield:

hydrogen cyanide (74-90-8) + 4-isopropenylcyclohexanone (22460-53-3) → cis-1-hydroxy-4-isopropenylcyclohexanecarbonitrile (461685-59-6) + trans-1-hydroxy-4-isopropenylcyclohexanecarbonitrile

Guidance literature:

With hydroxynitrile-lyase from cassava (S)-MeHNL; In di-isopropyl ether; for 9h; Further Variations:; Reagents; Product distribution;

DOI:10.1002/1521-3773(20020603)41:11<1876::AID-ANIE1876>3.0.CO;2-1

upstream raw materials:

hydrogen cyanide

4-isopropenylcyclohexanone

hydrogen isocyanide

Downstream raw materials:

cis-1-(hydroxymethyl)-4-isopropenylcyclohexane-1-ol

cis-(4-isopropenyl-1-trimethylsilyloxycyclohexyl)methanol

cis-4-isopropenyl-1-trimethylsilyloxycyclohexanecarbaldehyde

cis-4-isopropenyl-1-trimethylsilyloxycyclohexanecarbonitrile