cis-4-isopropenyl-1-trimethylsilyloxycyclohexanecarbonitrile

Base Information

• Chemical Name: cis-4-isopropenyl-1-trimethylsilyloxycyclohexanecarbonitrile
• CAS No.: 855303-72-9
• Molecular Formula: C₁₃H₂₃NOSi
• Molecular Weight: 237.417
• Mol file: 855303-72-9.mol

Synonyms:cis-4-isopropenyl-1-trimethylsilyloxycyclohexanecarbonitrile

Chemical Property of cis-4-isopropenyl-1-trimethylsilyloxycyclohexanecarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of cis-4-isopropenyl-1-trimethylsilyloxycyclohexanecarbonitrile

There total 2 articles about cis-4-isopropenyl-1-trimethylsilyloxycyclohexanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

chloro-trimethyl-silane (75-77-4) + cis-1-hydroxy-4-isopropenylcyclohexanecarbonitrile (461685-59-6) → cis-4-isopropenyl-1-trimethylsilyloxycyclohexanecarbonitrile (855303-72-9)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1002/chem.200401147

Reference yield:

4-isopropenylcyclohexanone (22460-53-3) → cis-4-isopropenyl-1-trimethylsilyloxycyclohexanecarbonitrile (855303-72-9)

Guidance literature:

Multi-step reaction with 2 steps

1: (S)-Me-hydroxynitrile lyase; HCN; nitrocellulose / diisopropyl ether / 5 h / 20 °C

2: 87 percent / imidazole / dimethylformamide / 1 h / 20 °C

With 1H-imidazole; hydrogen cyanide; (S)-Me-hydroxynitrile lyase; nitrocellulose; In di-isopropyl ether; N,N-dimethyl-formamide;

DOI:10.1002/chem.200401147

Reference yield: 70.0%

cis-4-isopropenyl-1-trimethylsilyloxycyclohexanecarbonitrile (855303-72-9) → cis-4-isopropenyl-1-trimethylsilyloxycyclohexanecarbaldehyde (855303-74-1)

Guidance literature:

With diisobutylaluminium hydride; In hexane; at 15 ℃; for 15h;

DOI:10.1002/chem.200401147

upstream raw materials:

chloro-trimethyl-silane

cis-1-hydroxy-4-isopropenylcyclohexanecarbonitrile

4-isopropenylcyclohexanone

Downstream raw materials:

cis-4-isopropenyl-1-trimethylsilyloxycyclohexanecarbaldehyde

cis-(4-isopropenyl-1-trimethylsilyloxycyclohexyl)methanol

cis-1-(hydroxymethyl)-4-isopropenylcyclohexane-1-ol