3-trimethylmethylcarbonyl-6-(phenyl)pyridoxal monomethylacetal

Base Information

• Chemical Name: 3-trimethylmethylcarbonyl-6-(phenyl)pyridoxal monomethylacetal
• CAS No.: 258531-71-4
• Molecular Formula: C₂₀H₂₃NO₄
• Molecular Weight: 341.407
• Mol file: 258531-71-4.mol

Synonyms:3-trimethylmethylcarbonyl-6-(phenyl)pyridoxal monomethylacetal

Chemical Property of 3-trimethylmethylcarbonyl-6-(phenyl)pyridoxal monomethylacetal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-trimethylmethylcarbonyl-6-(phenyl)pyridoxal monomethylacetal

There total 5 articles about 3-trimethylmethylcarbonyl-6-(phenyl)pyridoxal monomethylacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

phenylmagnesium chloride (100-59-4) + 7-(2,2-dimethyl-propionyloxy)-5-isobutoxycarbonyloxy-1-methoxy-6-methyl-1,3-dihydro-furo[3,4-c]pyridin-5-ium; chloride → 3-trimethylmethylcarbonyl-6-(phenyl)pyridoxal monomethylacetal (258531-71-4)

Guidance literature:

In tetrahydrofuran; at -78 - 25 ℃; for 2h;

DOI:10.1055/s-2000-6228

Reference yield:

7-hydroxy-1-methoxy-6-methyl-1H,3H-furo<3,4-c>pyridine (56583-59-6) → 3-trimethylmethylcarbonyl-6-(phenyl)pyridoxal monomethylacetal (258531-71-4)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 1 h / 25 °C

2: 54 percent / m-CPBA / CH₂Cl₂ / 2 h / 25 °C

3: tetrahydrofuran / 0.5 h / -78 °C

4: 85 percent / tetrahydrofuran / 2 h / -78 - 25 °C

With triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; 1: Esterification / 2: Oxidation / 3: Addition / 4: Grignard reaction;

DOI:10.1055/s-2000-6228

Reference yield:

pyridoxal hydrochloride (65-22-5) → 3-trimethylmethylcarbonyl-6-(phenyl)pyridoxal monomethylacetal (258531-71-4)

Guidance literature:

Multi-step reaction with 5 steps

1: NaHCO₃ / 1 h / Heating

2: Et₃N / CH₂Cl₂ / 1 h / 25 °C

3: 54 percent / m-CPBA / CH₂Cl₂ / 2 h / 25 °C

4: tetrahydrofuran / 0.5 h / -78 °C

5: 85 percent / tetrahydrofuran / 2 h / -78 - 25 °C

With sodium hydrogencarbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; 1: Cyclization / 2: Esterification / 3: Oxidation / 4: Addition / 5: Grignard reaction;

DOI:10.1055/s-2000-6228

upstream raw materials:

phenylmagnesium chloride

7-hydroxy-1-methoxy-6-methyl-1H,3H-furo<3,4-c>pyridine

pyridoxal hydrochloride

2,2-dimethyl-propionic acid 1-methoxy-6-methyl-1,3-dihydro-furo[3,4-c]pyridin-7-yl ester