Ethyl (4Z)-5-chloro-3-hydroxy-2-methylidene-5-(4-methylphenyl)pent-4-enoate

Base Information

Chemical Name:Ethyl (4Z)-5-chloro-3-hydroxy-2-methylidene-5-(4-methylphenyl)pent-4-enoate
CAS No.:1219452-58-0
Molecular Formula:C₁₅H₁₇ClO₃
Molecular Weight:280.751
Hs Code.:
DSSTox Substance ID:DTXSID60705009

Synonyms:1219452-58-0;DTXSID60705009;Ethyl (4Z)-5-chloro-3-hydroxy-2-methylidene-5-(4-methylphenyl)pent-4-enoate

Suppliers and Price of Ethyl (4Z)-5-chloro-3-hydroxy-2-methylidene-5-(4-methylphenyl)pent-4-enoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Ethyl (4Z)-5-chloro-3-hydroxy-2-methylidene-5-(4-methylphenyl)pent-4-enoate

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:280.0866221
Heavy Atom Count:19
Complexity:354

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C(=C)C(C=C(C1=CC=C(C=C1)C)Cl)O
Isomeric SMILES:CCOC(=O)C(=C)C(/C=C(/C1=CC=C(C=C1)C)\Cl)O

Technology Process of Ethyl (4Z)-5-chloro-3-hydroxy-2-methylidene-5-(4-methylphenyl)pent-4-enoate

There total 2 articles about Ethyl (4Z)-5-chloro-3-hydroxy-2-methylidene-5-(4-methylphenyl)pent-4-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 40808-08-0
(Z)-3-chloro-3-(p-tolyl)acrylaldehyde

: 140-88-5,9003-32-1
ethyl acrylate

: 1219452-58-0
ethyl (Z)-5-chloro-5-(4-chlorophenyl)-3-hydroxy-2-methylenepent-4-enoate

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; at 50 ℃; for 3h; Neat (no solvent); Sonication;
DOI:10.1080/00397910903262187

Reference yield: 33.0%

: 40808-08-0
(Z)-3-chloro-3-(p-tolyl)acrylaldehyde

: 70-55-3
toluene-4-sulfonamide

: 140-88-5,9003-32-1
ethyl acrylate

: 1219452-58-0
ethyl (Z)-5-chloro-5-(4-chlorophenyl)-3-hydroxy-2-methylenepent-4-enoate

: 1254255-17-8
(Z)-ethyl 5-chloro-2-methylene-3-(4-tolylsulfonamido)-5-(4-tolyl)pent-4-enoate

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; aluminum (III) chloride; at 20 ℃; for 72h; Neat (no solvent); Sonication;
DOI:10.3184/030823410X12627215361201

Reference yield: 91.0%

: 1219452-58-0
ethyl (Z)-5-chloro-5-(4-chlorophenyl)-3-hydroxy-2-methylenepent-4-enoate

: 1204966-40-4
ethyl (2Z,4Z)-2-(bromomethyl)-5-chloro-5-p-tolylpenta-2,4-dienoate

Guidance literature:: With bromine; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; stereoselective reaction;
DOI:10.1080/00397910903262187