2-fluoro-4-phenylbutanenitrile

Base Information

Chemical Name:2-fluoro-4-phenylbutanenitrile
CAS No.:1226495-17-5
Molecular Formula:C₁₀H₁₀FN
Molecular Weight:163.195
Hs Code.:

Synonyms:2-fluoro-4-phenylbutanenitrile

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Chemical Property of 2-fluoro-4-phenylbutanenitrile

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Technology Process of 2-fluoro-4-phenylbutanenitrile

There total 3 articles about 2-fluoro-4-phenylbutanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1209495-01-1
rac-1-cyano-3-phenylpropyl trifluoromethanesulfonate

: 1226495-17-5
2-fluoro-4-phenylbutanenitrile

Guidance literature:: With potassium fluoride; CH₃I*Cu⁽¹⁺⁾*Cl^(1-); In 1,4-dioxane; at 100 ℃; for 0.166667h; chemoselective reaction; Inert atmosphere; Glovebox;
DOI:10.1002/anie.201402238

Reference yield: 91.0%

: 104-53-0
3-phenyl-propionaldehyde

: potassium cyanide

: 7677-24-9
trimethylsilyl cyanide

: 1226495-17-5
2-fluoro-4-phenylbutanenitrile

Guidance literature:: 3-phenyl-propionaldehyde; potassium cyanide; trimethylsilyl cyanide; With 18-crown-6 ether; In dichloromethane; at 20 ℃; for 0.5h;

With difluoro-4-morpholinylsulfonium tetrafluoroborate; triethylamine tris(hydrogen fluoride); In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/jo100504x

Reference yield:

: 121054-03-3
2-hydroxy-4-phenylbutanenitrile

: 1226495-17-5
2-fluoro-4-phenylbutanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 2,6-dimethylpyridine / dichloromethane / 0.33 h / -78 °C / Inert atmosphere

2: potassium fluoride; CH₃I*Cu⁽¹⁺⁾*Cl^(1-) / 1,4-dioxane / 0.17 h / 100 °C / Inert atmosphere; Glovebox

With 2,6-dimethylpyridine; potassium fluoride; CH₃I*Cu⁽¹⁺⁾*Cl^(1-); In 1,4-dioxane; dichloromethane;
DOI:10.1002/anie.201402238