121054-03-3

Basic information

• Product Name: 2-hydroxy-4-phenylbutanenitrile
• Synonyms: 2-hydroxy-4-phenylbutanenitrile
• CAS NO: 121054-03-3
• Molecular Weight: 161.203
• Mol File: 121054-03-3.mol
• Article Data: 71

Chemical Properties

• CAS DataBase Reference: 2-hydroxy-4-phenylbutanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-4-phenylbutanenitrile(121054-03-3)
• EPA Substance Registry System: 2-hydroxy-4-phenylbutanenitrile(121054-03-3)

Safety Data

• Hazardous Substances Data: 121054-03-3(Hazardous Substances Data)

Upstream product

• 2046-18-6 4-phenylbutyronitrile 
• 104-53-0 3-phenyl-propionaldehyde 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 119798-23-1 acetic acid 1-cyano-3-phenylpropyl ester 
• 141377-52-8 4-phenyl-2-(trimethylsilyloxy)butyronitrile 
• 7677-24-9 trimethylsilyl cyanide 
• 773837-37-9 sodium cyanide 
• 67-56-1 methanol 
• 128302-78-3 α-(tert-butyldimethylsilyloxy)malonitrile 
• 151-50-8 potassium cyanide 
• 335087-69-9 (S)-(-)-4-phenyl-2-(trimethylsilyloxy)butanenitrile 
• 2043-61-0 cyclohexanecarbaldehyde 
• 74-90-8 hydrogen cyanide 
• 143-33-9 sodium cyanide 

Downstream Products

• 53279-93-9 rac-2-chloro-4-phenylbutanenitrile 
• 53279-92-8 (S)-2-hydroxy-4-phenylbutyronitrile 
• 120999-41-9 (R)-2-hydroxy-4-phenylbutanenitrile 
• 123356-14-9 (S)-2-acetyloxy-4-phenylbutanenitrile 
• 126641-88-1 (R)-(+)-acetoxy-4-phenyl-butanenitrile 
• 249766-35-6 2-[(1-ethoxy)ethoxy]-4-phenyl-butanenitrile 
• 117974-11-5 (D,L)-4-phenyl-2-hydroxy-1-butylamine 
• 1050264-88-4 (S)-1-cyano-3-phenylpropyl diisopropylcarbamate 
• 1209495-01-1 rac-1-cyano-3-phenylpropyl trifluoromethanesulfonate 
• 4354-47-6 (R)-2-cyclohexyl-2-hydroxyacetonitrile 
• 4354-47-6 (S)-2-cyclohexyl-2-hydroxyacetonitrile 

Relevant articles and documents

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Ionic liquid [omim][PF6] as an efficient and recyclable reaction media for the cyanosilylation of aldehydes without Lewis acid or any special activation

Ionic liquid [omim][PF6] has been demonstrated as an efficient and environmentally friendly reaction media as well as a promoter for the cyanosilylation of aldehydes under mild conditions. In addition, the recovered ionic liquid could be reused for subsequent runs with only a gradual decrease in activity.

Nickel-Catalyzed, Reductive C(sp3)?Si Cross-Coupling of α-Cyano Alkyl Electrophiles and Chlorosilanes

A nickel/zinc-catalyzed cross-electrophile coupling of alkyl electrophiles activated by an α-cyano group and chlorosilanes is reported. Elemental zinc is the stoichiometric reductant in this reductive coupling process. By this, a C(sp3)?Si bond can be formed starting from two electrophilic reactants whereas previous methods rely on the combination of carbon nucleophiles and silicon electrophiles or vice versa.

Access to β-Ketonitriles through Nickel-Catalyzed Carbonylative Coupling of α-Bromonitriles with Alkylzinc Reagents

Herein, we report a nickel-catalyzed carbonylative coupling of α-bromonitriles and alkylzinc reagents with near stoichiometric carbon monoxide to give β-ketonitriles in good yields. The reaction is catalyzed by a readily available and stable nickel(II) pincer complex. The developed protocol tolerates substrates bearing a variety of functional groups, which would be problematic or incompatible with previous synthetic methods. Additionally, we demonstrate the suitability of the method for carbon isotope labeling by the synthesis of 13C-labeled β-ketonitriles and their transformation into isotopically labeled heterocycles.