8-(4-(2-(5-acetylamino-2,2-dimethyl-1,3-dioxan-5-yl)ethyl)phenyl)octyl 4-methylbenzenesulfonate

Base Information

Chemical Name:8-(4-(2-(5-acetylamino-2,2-dimethyl-1,3-dioxan-5-yl)ethyl)phenyl)octyl 4-methylbenzenesulfonate
CAS No.:896472-89-2
Molecular Formula:C₃₁H₄₅NO₆S
Molecular Weight:559.767
Hs Code.:

Synonyms:8-(4-(2-(5-acetylamino-2,2-dimethyl-1,3-dioxan-5-yl)ethyl)phenyl)octyl 4-methylbenzenesulfonate

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Chemical Property of 8-(4-(2-(5-acetylamino-2,2-dimethyl-1,3-dioxan-5-yl)ethyl)phenyl)octyl 4-methylbenzenesulfonate

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Technology Process of 8-(4-(2-(5-acetylamino-2,2-dimethyl-1,3-dioxan-5-yl)ethyl)phenyl)octyl 4-methylbenzenesulfonate

There total 6 articles about 8-(4-(2-(5-acetylamino-2,2-dimethyl-1,3-dioxan-5-yl)ethyl)phenyl)octyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 896472-87-0
N-(5-(2-(4-(8-hydroxyoctyl)phenyl)ethyl)-2,2-dimethyl-1,3-dioxan-5-yl)ethanamide

: 98-59-9
p-toluenesulfonyl chloride

: 896472-89-2
8-(4-(2-(5-acetylamino-2,2-dimethyl-1,3-dioxan-5-yl)ethyl)phenyl)octyl 4-methylbenzenesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 15h;
DOI:10.1016/j.bmc.2006.01.071

Reference yield:

: 896472-85-8
N-(2,2-dimethyl-5-(2-(4-(4-oxobutyl)phenyl)ethyl)-1,3-dioxan-5-yl)ethanamide

: 896472-89-2
8-(4-(2-(5-acetylamino-2,2-dimethyl-1,3-dioxan-5-yl)ethyl)phenyl)octyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: 52 percent / sodium hydride / dimethylformamide / 0.5 h / -25 °C

2: 99 percent / hydrogen / Pd/C / ethyl acetate / 2 h

3: 72 percent / lithium aluminum hydride / diethyl ether / 2 h / 20 °C

4: 81 percent / triethylamine / CH₂Cl₂ / 15 h / 20 °C

With lithium aluminium tetrahydride; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1: Wittig condensation;
DOI:10.1016/j.bmc.2006.01.071

Reference yield:

: ethyl 8-(4-(2-(5-acetylamino-2,2-dimethyl-1,3-dioxan-5-yl)ethyl)phenyl)-2,4-octadienoate

: 896472-89-2
8-(4-(2-(5-acetylamino-2,2-dimethyl-1,3-dioxan-5-yl)ethyl)phenyl)octyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / hydrogen / Pd/C / ethyl acetate / 2 h

2: 72 percent / lithium aluminum hydride / diethyl ether / 2 h / 20 °C

3: 81 percent / triethylamine / CH₂Cl₂ / 15 h / 20 °C

With lithium aluminium tetrahydride; hydrogen; triethylamine; palladium on activated charcoal; In diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmc.2006.01.071