2-Methylthio-5-methylbenzoxazole

Base Information

• Chemical Name: 2-Methylthio-5-methylbenzoxazole
• CAS No.: 439608-30-7
• Molecular Formula: C₉H₉NOS
• Molecular Weight: 179.243
• Mol file: 439608-30-7.mol

Synonyms:2-METHYLTHIO-5-METHYLBENZOXAZOLE;5-Methyl-2-(methylthio)benzoxazole;2-Methylthio-6-methylbenzoxazole;5-Methyl-2-methylsulfanyl-benzooxazole

Chemical Property of 2-Methylthio-5-methylbenzoxazole

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Melting Point: 292 °C
• Refractive Index: 1.63
• Boiling Point: 292.2 °C at 760 mmHg
• Flash Point: 130.518 °C
• PSA: 51.33000
• Density: 1.23 g/cm³
• LogP: 2.85810

Purity/Quality:

99.0% ^*data from raw suppliers

5-Methyl-2-(methylthio)benzo[d]oxazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methylthio-5-methylbenzoxazole

There total 7 articles about 2-Methylthio-5-methylbenzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-methylbenzo[d]oxazole-2-thiol (22876-22-8) + methyl iodide (74-88-4) → 5-methyl-2-methylsulfanyl-benzooxazole (439608-30-7)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 3h;

Reference yield: 93.0%

4-methyl-1,3-benzoaxazolidine-2-thione (22876-22-8) + methyl iodide (74-88-4) → 5-methyl-2-methylsulfanyl-benzooxazole (439608-30-7)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 20h;

Reference yield: 55.0%

4-methyl-1,3-benzoaxazolidine-2-thione (22876-22-8) + methoxybenzene (100-66-3) → 5-methylbenzo[d]oxazol-2(3H)-one (22876-15-9) + 2-((4-methoxyphenyl)thio)-5-methylbenz[d]oxazole + 5-methyl-2-methylsulfanyl-benzooxazole (439608-30-7)

Guidance literature:

With dipotassium peroxodisulfate; trifluorormethanesulfonic acid; In neat (no solvent); at 20 ℃; for 12h; Temperature; regioselective reaction; Cooling with ice;

DOI:10.1021/jo501793q

upstream raw materials:

4-methyl-1,3-benzoaxazolidine-2-thione

methyl iodide

methoxybenzene

dimethyl sulfate