Methyl 5-methyl-4-oxo-1,4-dihydropyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

Base Information

• Chemical Name: Methyl 5-methyl-4-oxo-1,4-dihydropyrrolo[2,1-f][1,2,4]triazine-6-carboxylate
• CAS No.: 310431-29-9
• Molecular Formula: C₉H₉N₃O₃
• Molecular Weight: 207.189
• Hs Code.: 2933990090
• Mol file: 310431-29-9.mol

Synonyms:5-Methyl-4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazine-6-carboxylicacid methyl ester;

Chemical Property of Methyl 5-methyl-4-oxo-1,4-dihydropyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

Chemical Property:

• Vapor Pressure: 2.05E-06mmHg at 25°C
• Refractive Index: 1.66
• Boiling Point: 393.9 °C at 760 mmHg
• Flash Point: 192 °C
• PSA: 76.72000
• Density: 1.47 g/cm³
• LogP: 0.52990
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl5-methyl-4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazine-6-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 5-methyl-4-oxo-1,4-dihydropyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

There total 7 articles about Methyl 5-methyl-4-oxo-1,4-dihydropyrrolo[2,1-f][1,2,4]triazine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

dimethyl 1-amino-3-methyl-1H-pyrrole-2,4-dicarboxylate (310431-26-6) + formamide (77287-34-4,77287-35-5,60100-09-6) → 5-methyl-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester (310431-29-9)

Guidance literature:

at 165 ℃; for 6h;

Reference yield:

methyl 4-methyl-5-(2,2,2-trichloroacetyl)-1H-pyrrole-3-carboxylate → 5-methyl-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester (310431-29-9)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOMe

2: Ph₂P(O)ONH₂; NaH / dimethylformamide

3: Heating

With O-(diphenylphosphinyl)hydroxylamine; sodium methylate; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2004.12.079

Reference yield:

methyl 4-methyl-1H-pyrrole-3-carboxylate (40318-15-8) → 5-methyl-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester (310431-29-9)

Guidance literature:

Multi-step reaction with 4 steps

1: AlCl₃

2: NaOMe

3: Ph₂P(O)ONH₂; NaH / dimethylformamide

4: Heating

With aluminium trichloride; O-(diphenylphosphinyl)hydroxylamine; sodium methylate; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2004.12.079

upstream raw materials:

dimethyl 1-amino-3-methyl-1H-pyrrole-2,4-dicarboxylate

formamide

methyl 4-methyl-1H-pyrrole-3-carboxylate

dimethyl 3-methyl-1H-pyrrole-2,4-dicarboxylate

Downstream raw materials:

4-[(3-Hydroxy-4-methylphenyl)amino]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester

4-[(3-Hydroxy-4-methylphenyl)amino]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid

5-methyl-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid

methyl 4-(2-methyl-5-(methoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate