1-cyclohexyl-3-(methoxycarbonyl)-2-oxo-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide

Base Information

• Chemical Name: 1-cyclohexyl-3-(methoxycarbonyl)-2-oxo-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide
• CAS No.: 1141508-58-8
• Molecular Formula: C₁₉H₂₀N₂O₃
• Molecular Weight: 324.379

Synonyms:1-cyclohexyl-3-(methoxycarbonyl)-2-oxo-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide

Chemical Property of 1-cyclohexyl-3-(methoxycarbonyl)-2-oxo-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide

Chemical Property:

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Technology Process of 1-cyclohexyl-3-(methoxycarbonyl)-2-oxo-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide

There total 2 articles about 1-cyclohexyl-3-(methoxycarbonyl)-2-oxo-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methanol (67-56-1) + 1-cyclohexyl-3-(fluorocarbonyl)-2-oxo-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide (1141508-36-2) → 1-cyclohexyl-3-(methoxycarbonyl)-2-oxo-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide (1141508-58-8)

Guidance literature:

With triethylamine; Inert atmosphere; Reflux;

DOI:10.1002/ejoc.200801084

Reference yield:

isoquinoline (119-65-3) → 1-cyclohexyl-3-(methoxycarbonyl)-2-oxo-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide (1141508-58-8)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 14 h / 20 °C

2: triethylamine / Reflux

With triethylamine; In dichloromethane;

DOI:10.1021/bc1000966

Reference yield: 85.0%

1-cyclohexyl-3-(methoxycarbonyl)-2-oxo-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide (1141508-58-8) → 1-cyclohexyl-3-(methoxycarbonyl)-2-oxo-2,3,5,6-tetrahydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide (1141508-60-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 48h; under 760.051 Torr;

DOI:10.1002/ejoc.200801084

upstream raw materials:

methanol

1-cyclohexyl-3-(fluorocarbonyl)-2-oxo-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide

isoquinoline

Downstream raw materials:

1-cyclohexyl-3-(methoxycarbonyl)-2-oxo-2,3,5,6-tetrahydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide

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