1-cyclohexyl-3-(fluorocarbonyl)-2-oxo-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide

Base Information

• Chemical Name: 1-cyclohexyl-3-(fluorocarbonyl)-2-oxo-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide
• CAS No.: 1141508-36-2
• Molecular Formula: C₁₈H₁₇FN₂O₂
• Molecular Weight: 312.344

Synonyms:1-cyclohexyl-3-(fluorocarbonyl)-2-oxo-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide

Chemical Property of 1-cyclohexyl-3-(fluorocarbonyl)-2-oxo-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide

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Technology Process of 1-cyclohexyl-3-(fluorocarbonyl)-2-oxo-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide

There total 1 articles about 1-cyclohexyl-3-(fluorocarbonyl)-2-oxo-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

isoquinoline (119-65-3) + Cyclohexyl isocyanide (931-53-3) + trifluoroacetic anhydride (407-25-0) → 1-cyclohexyl-3-(fluorocarbonyl)-2-oxo-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide (1141508-36-2)

Guidance literature:

In dichloromethane; at -30 - 20 ℃; Inert atmosphere;

DOI:10.1002/ejoc.200801084

Reference yield: 99.0%

1-cyclohexyl-3-(fluorocarbonyl)-2-oxo-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide (1141508-36-2) + (S)-1-phenyl-ethylamine (2627-86-3) → (S)-1-cyclohexyl-2-oxo-3-(1-phenylethylcarbamoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide (1141508-56-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1002/ejoc.200801084

Reference yield: 82.0%

methanol (67-56-1) + 1-cyclohexyl-3-(fluorocarbonyl)-2-oxo-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide (1141508-36-2) → 1-cyclohexyl-3-(methoxycarbonyl)-2-oxo-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide (1141508-58-8)

Guidance literature:

With triethylamine; Inert atmosphere; Reflux;

DOI:10.1002/ejoc.200801084

upstream raw materials:

isoquinoline

Cyclohexyl isocyanide

trifluoroacetic anhydride

Downstream raw materials:

1-cyclohexyl-3-(methoxycarbonyl)-2-oxo-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide

(S)-1-cyclohexyl-2-oxo-3-(1-phenylethylcarbamoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide

1-cyclohexyl-3-(4-methoxybenzylcarbamoyl)-2-oxo-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide

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