[1-(2-Chloro-ethyl)-3-(4-methoxy-phenyl)-2-oxo-2λ⁵-[1,3,2]diazaphospholidin-2-yl]-phenyl-amine

Base Information

• Chemical Name: [1-(2-Chloro-ethyl)-3-(4-methoxy-phenyl)-2-oxo-2λ⁵-[1,3,2]diazaphospholidin-2-yl]-phenyl-amine
• CAS No.: 183055-95-0
• Molecular Formula: C₁₇H₂₁ClN₃O₂P
• Molecular Weight: 365.799

Synonyms:[1-(2-Chloro-ethyl)-3-(4-methoxy-phenyl)-2-oxo-2λ⁵-[1,3,2]diazaphospholidin-2-yl]-phenyl-amine

Chemical Property of [1-(2-Chloro-ethyl)-3-(4-methoxy-phenyl)-2-oxo-2λ⁵-[1,3,2]diazaphospholidin-2-yl]-phenyl-amine

Chemical Property:

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Technology Process of [1-(2-Chloro-ethyl)-3-(4-methoxy-phenyl)-2-oxo-2λ⁵-[1,3,2]diazaphospholidin-2-yl]-phenyl-amine

There total 3 articles about [1-(2-Chloro-ethyl)-3-(4-methoxy-phenyl)-2-oxo-2λ⁵-[1,3,2]diazaphospholidin-2-yl]-phenyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

sodium methylate (124-41-4) + N-bis(2-chloroethyl)-N'-(4-methoxyphenyl)-N''-phenylphosphotriamidate (183055-93-8) → [1-(2-Chloro-ethyl)-3-(4-methoxy-phenyl)-2-oxo-2λ5-[1,3,2]diazaphospholidin-2-yl]-phenyl-amine (183055-95-0) + [1-(2-Chloro-ethyl)-2-oxo-3-phenyl-2λ5-[1,3,2]diazaphospholidin-2-yl]-(4-methoxy-phenyl)-amine

Guidance literature:

In methanol; for 20h; Ambient temperature;

DOI:10.1055/s-1996-4364

Reference yield:

N-bis(2-chloroethyl)-N'-phenylphosphodiamidochloridate (53382-80-2) → [1-(2-Chloro-ethyl)-3-(4-methoxy-phenyl)-2-oxo-2λ5-[1,3,2]diazaphospholidin-2-yl]-phenyl-amine (183055-95-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 96 h / Ambient temperature

2: methanol / 20 h / Ambient temperature

With triethylamine; In methanol; dichloromethane;

DOI:10.1055/s-1996-4364

Reference yield:

aniline (62-53-3) → [1-(2-Chloro-ethyl)-3-(4-methoxy-phenyl)-2-oxo-2λ5-[1,3,2]diazaphospholidin-2-yl]-phenyl-amine (183055-95-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 64 percent / CH₂Cl₂ / 240 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / 96 h / Ambient temperature

3: methanol / 20 h / Ambient temperature

With triethylamine; In methanol; dichloromethane;

DOI:10.1055/s-1996-4364

upstream raw materials:

sodium methylate

N-bis(2-chloroethyl)-N'-(4-methoxyphenyl)-N''-phenylphosphotriamidate

N-bis(2-chloroethyl)-N'-phenylphosphodiamidochloridate

aniline

Downstream raw materials:

1-(4-Methoxy-phenyl)-7-phenyl-tetrahydro-[1,3,2]diazaphospholo[1,2-a][1,3,2]diazaphosphole 8-oxide

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