Synonyms:4-amino-2-phenylbutyric acid;alpha-phenyl-gamma-aminobutyric acid;alpha-phenyl-gamma-aminobutyric acid, hydrochloride
99% *data from raw suppliers
4-Amino-2-phenylbutanoicacid 95+% *data from reagent suppliers
There total 9 articles about 4-Amino-2-phenylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 99.0%
Reference yield: 5.0%
Reference yield:
The research focuses on the isomerization of glycidic esters to β-hydroxy-α,ω-unsaturated esters (allylic alcohols) using HClO4·SiO2 as an efficient catalyst. This method was applied in the formal synthesis of (R)-Baclofen and α-phenyl GABA analogues. The study found that HClO4·SiO2 is a stable and effective reagent for this transformation, yielding allylic alcohols in good to high yields. These allylic alcohols were then converted into GABA derivatives through selective SN2 nucleophilic substitution with azide ion, followed by hydrogenation and reduction steps. The key chemicals involved in this research include glycidic esters derived from various ketones, HClO4·SiO2 as the catalyst, azide ion for the nucleophilic substitution, and palladium on carbon (Pd/C) for hydrogenation. The study also utilized methanesulfonyl chloride (MsCl) and sodium azide (NaN3) in the conversion process. The results demonstrate a new and efficient route for synthesizing important GABA derivatives, such as Baclofen, using readily available reagents and mild reaction conditions.
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