1-Boc-4-ethoxycarbonylmethylpiperazine

Base Information

• Chemical Name: 1-Boc-4-ethoxycarbonylmethylpiperazine
• CAS No.: 209667-59-4
• Molecular Formula: C13H24 N2 O4
• Molecular Weight: 272.345
• Hs Code.: 2933599090
• Mol file: 209667-59-4.mol

Synonyms:4-(tert-Butoxycarbonyl)-1-(ethoxycarbonylmethyl)piperazine;tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperazine-1-carboxylate; tert-Butyl4-[(ethoxycarbonyl)methyl]piperazine-1-carboxylate

Chemical Property of 1-Boc-4-ethoxycarbonylmethylpiperazine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 346.092°C at 760 mmHg
• Flash Point: 163.111°C
• PSA: 59.08000
• Density: 1.09g/cm³
• LogP: 0.97800
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-Boc-4-ethoxycarbonylmethylpiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-4-ethoxycarbonylmethylpiperazine

There total 6 articles about 1-Boc-4-ethoxycarbonylmethylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl bromoacetate (105-36-2) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(2-ethoxy-2-oxoethyl)piperazine-1-carboxylic acid (209667-59-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield: 94.0%

di-tert-butyl dicarbonate (24424-99-5) + 1-(Ethoxycarbonylmethyl)piperazine (40004-08-8) → tert-butyl 4-(2-ethoxy-2-oxoethyl)piperazine-1-carboxylic acid (209667-59-4)

Guidance literature:

With triethylamine; In dichloromethane; at 22 ℃; for 24h;

Reference yield: 91.0%

chloroacetic acid ethyl ester (105-39-5) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(2-ethoxy-2-oxoethyl)piperazine-1-carboxylic acid (209667-59-4)

Guidance literature:

With N-benzyl-trimethylammonium hydroxide; at 20 ℃; Neat (no solvent);

DOI:10.1080/00397910802654740

upstream raw materials:

ethyl iodoacetae

1-t-Butoxycarbonylpiperazine

di-tert-butyl dicarbonate

1-(Ethoxycarbonylmethyl)piperazine

Downstream raw materials:

1-(Ethoxycarbonylmethyl)piperazine

(4-phenylmethanesulfonyl-piperazin-1-yl)-acetic acid

4-[(1,1-Dimethylethoxy)carbonyl]-1-piperazineacetic acid

C₁₄H₂₀N₂O₄S