3-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]-2-methylpropionic acid

Base Information

Chemical Name:3-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]-2-methylpropionic acid
CAS No.:590402-37-2
Molecular Formula:C₂₆H₂₇ClN₄O₅
Molecular Weight:510.977
Hs Code.:

Synonyms:3-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]-2-methylpropionic acid

Suppliers and Price of 3-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]-2-methylpropionic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]-2-methylpropionic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]-2-methylpropionic acid

There total 6 articles about 3-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]-2-methylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 590402-36-1
3-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]-2-methylpropionic acid tert-butyl ester

: 590402-37-2
3-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]-2-methylpropionic acid

Guidance literature:: With chlorotriisopropylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.166667h;
DOI:10.1039/b302239k

Reference yield:

: 501-97-3
4-hydroxyphenylpropionic acid

: 590402-37-2
3-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]-2-methylpropionic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: carbonyldiimidazole / dimethylformamide / 48 h / 40 °C

1.2: 65 percent / DBU / dimethylformamide / 2 h / 65 °C

2.1: 79 percent / DMAP; Et₃N / CH₂Cl₂ / 8 h / 20 °C

3.1: 60 percent / LDA; HMPA / tetrahydrofuran / 18 h / -78 - 20 °C

4.1: 82 percent / TBAF / tetrahydrofuran / 0.33 h / 20 °C

5.1: 33 percent / diethyl azodicarboxylate; Ph₃P / CH₂Cl₂ / 3 h / 20 °C

6.1: 81 percent / triisopropylsilane; trifluoroacetic acid / CH₂Cl₂ / 0.17 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; chlorotriisopropylsilane; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; lithium diisopropyl amide; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 5.1: Mitsunobu alkylation;
DOI:10.1039/b302239k

Reference yield:

: 51458-31-2
3-(4-hydroxyphenyl)propionic acid tert-butyl ester

: 590402-37-2
3-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]-2-methylpropionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 79 percent / DMAP; Et₃N / CH₂Cl₂ / 8 h / 20 °C

2: 60 percent / LDA; HMPA / tetrahydrofuran / 18 h / -78 - 20 °C

3: 82 percent / TBAF / tetrahydrofuran / 0.33 h / 20 °C

4: 33 percent / diethyl azodicarboxylate; Ph₃P / CH₂Cl₂ / 3 h / 20 °C

5: 81 percent / triisopropylsilane; trifluoroacetic acid / CH₂Cl₂ / 0.17 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; chlorotriisopropylsilane; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; trifluoroacetic acid; lithium diisopropyl amide; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 4: Mitsunobu alkylation;
DOI:10.1039/b302239k