3-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]-2-methylpropionic acid 2-(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethoxy)ethyl ester

Base Information

Chemical Name:3-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]-2-methylpropionic acid 2-(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethoxy)ethyl ester
CAS No.:590402-38-3
Molecular Formula:C₃₆H₄₇ClN₄O₁₀
Molecular Weight:731.243
Hs Code.:

3-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]-2-methylpropionic acid 2-(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethoxy)ethyl ester

Synonyms:3-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]-2-methylpropionic acid 2-(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethoxy)ethyl ester

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Chemical Property of 3-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]-2-methylpropionic acid 2-(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethoxy)ethyl ester

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Technology Process of 3-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]-2-methylpropionic acid 2-(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethoxy)ethyl ester

There total 7 articles about 3-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]-2-methylpropionic acid 2-(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethoxy)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 4792-15-8
Pentaethylene glycol

: 590402-37-2
3-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]-2-methylpropionic acid

: 590402-38-3
3-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]-2-methylpropionic acid 2-(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethoxy)ethyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1039/b302239k

Reference yield:

: 501-97-3
4-hydroxyphenylpropionic acid

: 590402-38-3
3-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]-2-methylpropionic acid 2-(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethoxy)ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: carbonyldiimidazole / dimethylformamide / 48 h / 40 °C

1.2: 65 percent / DBU / dimethylformamide / 2 h / 65 °C

2.1: 79 percent / DMAP; Et₃N / CH₂Cl₂ / 8 h / 20 °C

3.1: 60 percent / LDA; HMPA / tetrahydrofuran / 18 h / -78 - 20 °C

4.1: 82 percent / TBAF / tetrahydrofuran / 0.33 h / 20 °C

5.1: 33 percent / diethyl azodicarboxylate; Ph₃P / CH₂Cl₂ / 3 h / 20 °C

6.1: 81 percent / triisopropylsilane; trifluoroacetic acid / CH₂Cl₂ / 0.17 h / 20 °C

7.1: 56 percent / diethyl azodicarboxylate; Ph₃P / CH₂Cl₂ / 4 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; chlorotriisopropylsilane; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; lithium diisopropyl amide; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 5.1: Mitsunobu alkylation / 7.1: Mitsunobu alkylation;
DOI:10.1039/b302239k

Reference yield:

: 51458-31-2
3-(4-hydroxyphenyl)propionic acid tert-butyl ester

: 590402-38-3
3-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]-2-methylpropionic acid 2-(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethoxy)ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 79 percent / DMAP; Et₃N / CH₂Cl₂ / 8 h / 20 °C

2: 60 percent / LDA; HMPA / tetrahydrofuran / 18 h / -78 - 20 °C

3: 82 percent / TBAF / tetrahydrofuran / 0.33 h / 20 °C

4: 33 percent / diethyl azodicarboxylate; Ph₃P / CH₂Cl₂ / 3 h / 20 °C

5: 81 percent / triisopropylsilane; trifluoroacetic acid / CH₂Cl₂ / 0.17 h / 20 °C

6: 56 percent / diethyl azodicarboxylate; Ph₃P / CH₂Cl₂ / 4 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; chlorotriisopropylsilane; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; trifluoroacetic acid; lithium diisopropyl amide; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 4: Mitsunobu alkylation / 6: Mitsunobu alkylation;
DOI:10.1039/b302239k