(E)-3-{4-[(6-{3-[(E)-2-cyano-2-(5-formylthiophen-2-yl )vinyl]phenoxazin-10-yl}hexyl)phenylamino]phenyl}-2-(5-formylthiophen-2-yl)acrylonitrile

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Chemical Name:(E)-3-{4-[(6-{3-[(E)-2-cyano-2-(5-formylthiophen-2-yl )vinyl]phenoxazin-10-yl}hexyl)phenylamino]phenyl}-2-(5-formylthiophen-2-yl)acrylonitrile
CAS No.:1334037-48-7
Molecular Formula:C₄₆H₃₆N₄O₃S₂
Molecular Weight:756.949
Hs Code.:

Synonyms:(E)-3-{4-[(6-{3-[(E)-2-cyano-2-(5-formylthiophen-2-yl )vinyl]phenoxazin-10-yl}hexyl)phenylamino]phenyl}-2-(5-formylthiophen-2-yl)acrylonitrile

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Chemical Property of (E)-3-{4-[(6-{3-[(E)-2-cyano-2-(5-formylthiophen-2-yl )vinyl]phenoxazin-10-yl}hexyl)phenylamino]phenyl}-2-(5-formylthiophen-2-yl)acrylonitrile

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Technology Process of (E)-3-{4-[(6-{3-[(E)-2-cyano-2-(5-formylthiophen-2-yl )vinyl]phenoxazin-10-yl}hexyl)phenylamino]phenyl}-2-(5-formylthiophen-2-yl)acrylonitrile

There total 6 articles about (E)-3-{4-[(6-{3-[(E)-2-cyano-2-(5-formylthiophen-2-yl )vinyl]phenoxazin-10-yl}hexyl)phenylamino]phenyl}-2-(5-formylthiophen-2-yl)acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.1%

: 1334037-47-6
(E)-3-[4-({6-[3-((E)-2-cyano-2-thiophen-2-yl-vinyl)phenoxazin-10-yl]hexyl}phenylamino)phenyl]-2-thiophen-2-ylacrylonitrile

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1334037-48-7
(E)-3-{4-[(6-{3-[(E)-2-cyano-2-(5-formylthiophen-2-yl )vinyl]phenoxazin-10-yl}hexyl)phenylamino]phenyl}-2-(5-formylthiophen-2-yl)acrylonitrile

Guidance literature:: (E)-3-[4-({6-[3-((E)-2-cyano-2-thiophen-2-yl-vinyl)phenoxazin-10-yl]hexyl}phenylamino)phenyl]-2-thiophen-2-ylacrylonitrile; N,N-dimethyl-formamide; With trichlorophosphate; In 1,2-dichloro-ethane; at 0 - 90 ℃; for 2h; Inert atmosphere;

With water; sodium hydroxide; In 1,2-dichloro-ethane; Inert atmosphere;
DOI:10.1021/jo201057b

Reference yield:

: 629-03-8
1 ,6-dibromohexane

: 1334037-48-7
(E)-3-{4-[(6-{3-[(E)-2-cyano-2-(5-formylthiophen-2-yl )vinyl]phenoxazin-10-yl}hexyl)phenylamino]phenyl}-2-(5-formylthiophen-2-yl)acrylonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / 1,2-dimethoxyethane / 0.5 h / 20 °C / Inert atmosphere

1.2: 2 h / 85 °C / Inert atmosphere

2.1: potassium hydroxide / dimethyl sulfoxide / 0.5 h / 20 °C / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

3.1: trichlorophosphate / 1,2-dichloro-ethane / 5 h / 0 - 90 °C / Inert atmosphere

4.1: potassium tert-butylate / tetrahydrofuran / 1 h / Inert atmosphere; Reflux

5.1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / 0 - 90 °C / Inert atmosphere

5.2: Inert atmosphere

With potassium tert-butylate; sodium hydride; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,2-dimethoxyethane; dimethyl sulfoxide; 1,2-dichloro-ethane; 3.1: Vilsmeier formylation / 4.1: Knoevenagel condensation / 5.1: Vilsmeier formylation;
DOI:10.1021/jo201057b

Reference yield:

: 1334037-45-4
(6-phenoxazin-10-yl-hexyl)diphenylamine

: 1334037-48-7
(E)-3-{4-[(6-{3-[(E)-2-cyano-2-(5-formylthiophen-2-yl )vinyl]phenoxazin-10-yl}hexyl)phenylamino]phenyl}-2-(5-formylthiophen-2-yl)acrylonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 1,2-dichloro-ethane / 5 h / 0 - 90 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 1 h / Inert atmosphere; Reflux

3.1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / 0 - 90 °C / Inert atmosphere

3.2: Inert atmosphere

With potassium tert-butylate; trichlorophosphate; In tetrahydrofuran; 1,2-dichloro-ethane; 1.1: Vilsmeier formylation / 2.1: Knoevenagel condensation / 3.1: Vilsmeier formylation;
DOI:10.1021/jo201057b