(E)-3-{5-[(E)-2-(4-{[6-(3-{(E)-2-[5-((E)-2-carboxy-2-cyanovinyl)thiophen-2-yl]-2-cyanovinyl}phenoxazin-10-yl)hexyl]phenylamino}phenyl)-1-cyanovinyl]thiophen-2-yl}-2-cyanoacrylic acid

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Chemical Name:(E)-3-{5-[(E)-2-(4-{[6-(3-{(E)-2-[5-((E)-2-carboxy-2-cyanovinyl)thiophen-2-yl]-2-cyanovinyl}phenoxazin-10-yl)hexyl]phenylamino}phenyl)-1-cyanovinyl]thiophen-2-yl}-2-cyanoacrylic acid
CAS No.:1334037-49-8
Molecular Formula:C₅₂H₃₈N₆O₅S₂
Molecular Weight:891.043
Hs Code.:

(E)-3-{5-[(E)-2-(4-{[6-(3-{(E)-2-[5-((E)-2-carboxy-2-cyanovinyl)thiophen-2-yl]-2-cyanovinyl}phenoxazin-10-yl)hexyl]phenylamino}phenyl)-1-cyanovinyl]thiophen-2-yl}-2-cyanoacrylic acid

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Chemical Property of (E)-3-{5-[(E)-2-(4-{[6-(3-{(E)-2-[5-((E)-2-carboxy-2-cyanovinyl)thiophen-2-yl]-2-cyanovinyl}phenoxazin-10-yl)hexyl]phenylamino}phenyl)-1-cyanovinyl]thiophen-2-yl}-2-cyanoacrylic acid

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Technology Process of (E)-3-{5-[(E)-2-(4-{[6-(3-{(E)-2-[5-((E)-2-carboxy-2-cyanovinyl)thiophen-2-yl]-2-cyanovinyl}phenoxazin-10-yl)hexyl]phenylamino}phenyl)-1-cyanovinyl]thiophen-2-yl}-2-cyanoacrylic acid

There total 7 articles about (E)-3-{5-[(E)-2-(4-{[6-(3-{(E)-2-[5-((E)-2-carboxy-2-cyanovinyl)thiophen-2-yl]-2-cyanovinyl}phenoxazin-10-yl)hexyl]phenylamino}phenyl)-1-cyanovinyl]thiophen-2-yl}-2-cyanoacrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.7%

: 1334037-48-7
(E)-3-{4-[(6-{3-[(E)-2-cyano-2-(5-formylthiophen-2-yl )vinyl]phenoxazin-10-yl}hexyl)phenylamino]phenyl}-2-(5-formylthiophen-2-yl)acrylonitrile

: 372-09-8
cyanoacetic acid

: 1334037-49-8
(E)-3-{5-[(E)-2-(4-{[6-(3-{(E)-2-[5-((E)-2-carboxy-2-cyanovinyl)thiophen-2-yl]-2-cyanovinyl}phenoxazin-10-yl)hexyl]phenylamino}phenyl)-1-cyanovinyl]thiophen-2-yl}-2-cyanoacrylic acid

Guidance literature:: (E)-3-{4-[(6-{3-[(E)-2-cyano-2-(5-formylthiophen-2-yl )vinyl]phenoxazin-10-yl}hexyl)phenylamino]phenyl}-2-(5-formylthiophen-2-yl)acrylonitrile; cyanoacetic acid; With piperidine; In chloroform; for 2h; Inert atmosphere; Reflux;

With hydrogenchloride; In dichloromethane; chloroform; water; Inert atmosphere;
DOI:10.1021/jo201057b

Reference yield:

: 1334037-47-6
(E)-3-[4-({6-[3-((E)-2-cyano-2-thiophen-2-yl-vinyl)phenoxazin-10-yl]hexyl}phenylamino)phenyl]-2-thiophen-2-ylacrylonitrile

: 1334037-49-8
(E)-3-{5-[(E)-2-(4-{[6-(3-{(E)-2-[5-((E)-2-carboxy-2-cyanovinyl)thiophen-2-yl]-2-cyanovinyl}phenoxazin-10-yl)hexyl]phenylamino}phenyl)-1-cyanovinyl]thiophen-2-yl}-2-cyanoacrylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / 0 - 90 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: piperidine / chloroform / 2 h / Inert atmosphere; Reflux

2.2: Inert atmosphere

With piperidine; trichlorophosphate; In chloroform; 1,2-dichloro-ethane; 1.1: Vilsmeier formylation / 2.1: Knoevenagel condensation;
DOI:10.1021/jo201057b

Reference yield:

: 629-03-8
1 ,6-dibromohexane

: 1334037-49-8
(E)-3-{5-[(E)-2-(4-{[6-(3-{(E)-2-[5-((E)-2-carboxy-2-cyanovinyl)thiophen-2-yl]-2-cyanovinyl}phenoxazin-10-yl)hexyl]phenylamino}phenyl)-1-cyanovinyl]thiophen-2-yl}-2-cyanoacrylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / 1,2-dimethoxyethane / 0.5 h / 20 °C / Inert atmosphere

1.2: 2 h / 85 °C / Inert atmosphere

2.1: potassium hydroxide / dimethyl sulfoxide / 0.5 h / 20 °C / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

3.1: trichlorophosphate / 1,2-dichloro-ethane / 5 h / 0 - 90 °C / Inert atmosphere

4.1: potassium tert-butylate / tetrahydrofuran / 1 h / Inert atmosphere; Reflux

5.1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / 0 - 90 °C / Inert atmosphere

5.2: Inert atmosphere

6.1: piperidine / chloroform / 2 h / Inert atmosphere; Reflux

6.2: Inert atmosphere

With piperidine; potassium tert-butylate; sodium hydride; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,2-dimethoxyethane; chloroform; dimethyl sulfoxide; 1,2-dichloro-ethane; 3.1: Vilsmeier formylation / 4.1: Knoevenagel condensation / 5.1: Vilsmeier formylation / 6.1: Knoevenagel condensation;
DOI:10.1021/jo201057b