(E)-3-[4-({6-[3-((E)-2-cyano-2-thiophen-2-yl-vinyl)phenoxazin-10-yl]hexyl}phenylamino)phenyl]-2-thiophen-2-ylacrylonitrile

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Chemical Name:(E)-3-[4-({6-[3-((E)-2-cyano-2-thiophen-2-yl-vinyl)phenoxazin-10-yl]hexyl}phenylamino)phenyl]-2-thiophen-2-ylacrylonitrile
CAS No.:1334037-47-6
Molecular Formula:C₄₄H₃₆N₄OS₂
Molecular Weight:700.928
Hs Code.:

Synonyms:(E)-3-[4-({6-[3-((E)-2-cyano-2-thiophen-2-yl-vinyl)phenoxazin-10-yl]hexyl}phenylamino)phenyl]-2-thiophen-2-ylacrylonitrile

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Chemical Property of (E)-3-[4-({6-[3-((E)-2-cyano-2-thiophen-2-yl-vinyl)phenoxazin-10-yl]hexyl}phenylamino)phenyl]-2-thiophen-2-ylacrylonitrile

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Technology Process of (E)-3-[4-({6-[3-((E)-2-cyano-2-thiophen-2-yl-vinyl)phenoxazin-10-yl]hexyl}phenylamino)phenyl]-2-thiophen-2-ylacrylonitrile

There total 5 articles about (E)-3-[4-({6-[3-((E)-2-cyano-2-thiophen-2-yl-vinyl)phenoxazin-10-yl]hexyl}phenylamino)phenyl]-2-thiophen-2-ylacrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.8%

: 20893-30-5
2-cyanomethylthiophene

: 1334037-46-5
10-{6-[(4-formylphenyl)phenylamino]hexyl}-10H-phenoxazine-3-carbaldehyde

: 1334037-47-6
(E)-3-[4-({6-[3-((E)-2-cyano-2-thiophen-2-yl-vinyl)phenoxazin-10-yl]hexyl}phenylamino)phenyl]-2-thiophen-2-ylacrylonitrile

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; for 1h; Inert atmosphere; Reflux;
DOI:10.1021/jo201057b

Reference yield:

: 629-03-8
1 ,6-dibromohexane

: 1334037-47-6
(E)-3-[4-({6-[3-((E)-2-cyano-2-thiophen-2-yl-vinyl)phenoxazin-10-yl]hexyl}phenylamino)phenyl]-2-thiophen-2-ylacrylonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / 1,2-dimethoxyethane / 0.5 h / 20 °C / Inert atmosphere

1.2: 2 h / 85 °C / Inert atmosphere

2.1: potassium hydroxide / dimethyl sulfoxide / 0.5 h / 20 °C / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

3.1: trichlorophosphate / 1,2-dichloro-ethane / 5 h / 0 - 90 °C / Inert atmosphere

4.1: potassium tert-butylate / tetrahydrofuran / 1 h / Inert atmosphere; Reflux

With potassium tert-butylate; sodium hydride; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,2-dimethoxyethane; dimethyl sulfoxide; 1,2-dichloro-ethane; 3.1: Vilsmeier formylation / 4.1: Knoevenagel condensation;
DOI:10.1021/jo201057b

Reference yield:

: 1027856-54-7
(6-bromohexyl)diphenylamine

: 1334037-47-6
(E)-3-[4-({6-[3-((E)-2-cyano-2-thiophen-2-yl-vinyl)phenoxazin-10-yl]hexyl}phenylamino)phenyl]-2-thiophen-2-ylacrylonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 0.5 h / 20 °C / Inert atmosphere

1.2: 3 h / 20 °C / Inert atmosphere

2.1: trichlorophosphate / 1,2-dichloro-ethane / 5 h / 0 - 90 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 1 h / Inert atmosphere; Reflux

With potassium tert-butylate; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; dimethyl sulfoxide; 1,2-dichloro-ethane; 2.1: Vilsmeier formylation / 3.1: Knoevenagel condensation;
DOI:10.1021/jo201057b