(2-Hydroxy-3-chloro-4-methyl)pentyl phenyl ketone

Base Information

• Chemical Name: (2-Hydroxy-3-chloro-4-methyl)pentyl phenyl ketone
• CAS No.: 108686-20-0
• Molecular Formula: C₁₃H₁₇ClO₂
• Molecular Weight: 240.73
• Mol file: 108686-20-0.mol

Synonyms:(2-Hydroxy-3-chloro-4-methyl)pentyl phenyl ketone

Chemical Property of (2-Hydroxy-3-chloro-4-methyl)pentyl phenyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (2-Hydroxy-3-chloro-4-methyl)pentyl phenyl ketone

There total 2 articles about (2-Hydroxy-3-chloro-4-methyl)pentyl phenyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-3-methyl-butanal (53394-32-4) + acetophenone (98-86-2) → (2-Hydroxy-3-chloro-4-methyl)pentyl phenyl ketone (108686-20-0)

Guidance literature:

With magnesium bromide; lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 1 h;

DOI:10.1055/s-1987-27933

Reference yield:

isovaleraldehyde (590-86-3) → (2-Hydroxy-3-chloro-4-methyl)pentyl phenyl ketone (108686-20-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-chloro-succinimide; L-proline / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 - 0 °C / Inert atmosphere

2.2: 0.5 h / -78 °C / Inert atmosphere

With N-chloro-succinimide; n-butyllithium; diisopropylamine; L-proline; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1002/ejoc.201300305

Reference yield:

(2-Hydroxy-3-chloro-4-methyl)pentyl phenyl ketone (108686-20-0) → 2-iso-propyl-5-phenylfuran (58509-74-3)

Guidance literature:

With pyridinium p-toluenesulfonate; In water; for 12h; Reflux; Inert atmosphere;

DOI:10.1002/ejoc.201300305

upstream raw materials:

2-chloro-3-methyl-butanal

acetophenone

isovaleraldehyde

Downstream raw materials:

2-iso-propyl-5-phenylfuran