(2R,5S)-2-dimethylamino-3-phenyl-1,3-diazaphosphabicyclo[3.3.0^1,5]octane

Base Information

• Chemical Name: (2R,5S)-2-dimethylamino-3-phenyl-1,3-diazaphosphabicyclo[3.3.0^1,5]octane
• CAS No.: 232618-88-1
• Molecular Formula: C₁₃H₂₀N₃P
• Molecular Weight: 249.296
• Mol file: 232618-88-1.mol

Synonyms:(2R,5S)-2-dimethylamino-3-phenyl-1,3-diazaphosphabicyclo[3.3.0^1,5]octane

Chemical Property of (2R,5S)-2-dimethylamino-3-phenyl-1,3-diazaphosphabicyclo[3.3.0^1,5]octane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,5S)-2-dimethylamino-3-phenyl-1,3-diazaphosphabicyclo[3.3.0^1,5]octane

There total 5 articles about (2R,5S)-2-dimethylamino-3-phenyl-1,3-diazaphosphabicyclo[3.3.0^1,5]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(2S)-2-(anilinomethyl)pyrrolidine (64030-44-0) + Hexamethylphosphorous triamide (1608-26-0) → (1R,8S)-1-(dimethylamino)-2-phenyl-2,7-diaza-1-phosphabicyclo[3.3.0]octane (232618-88-1)

Guidance literature:

In toluene; for 4h; Heating;

DOI:10.1002/chem.200400316

Reference yield:

(2S)-2-(anilinomethyl)pyrrolidine (64030-44-0) + Hexamethylphosphorous triamide (1608-26-0) → (2R,5S)-2-dimethylamino-3-phenyl-1,3-diazaphosphabicyclo[3.3.01,5]octane (232618-88-1)

Guidance literature:

In toluene; for 2h; Heating;

DOI:10.1055/s-1998-1561

Reference yield:

L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) → (2R,5S)-2-dimethylamino-3-phenyl-1,3-diazaphosphabicyclo[3.3.01,5]octane (232618-88-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / 4 h / 195 - 200 °C

2: 92 percent / LiAlH₄ / tetrahydrofuran

3: toluene / 2 h / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran; toluene; 1: Cyclization / 2: Reduction / 3: Cyclization;

DOI:10.1021/jo990205u

upstream raw materials:

(2S)-2-(anilinomethyl)pyrrolidine

Hexamethylphosphorous triamide

L-glutamic acid

aniline

Downstream raw materials:

C₁₂H₁₇N₂OP

C₂₅H₂₇N₂OP

C₂₇H₂₅N₂OP

1-(biphenyl-2-yloxy)-2-phenyl-hexahydro-pyrrolo[1,2-c][1,3,2]diazaphopsphole