4-(4-fluorophenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid 4-hydroxymethylbenzylamide

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Chemical Name:4-(4-fluorophenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid 4-hydroxymethylbenzylamide
CAS No.:855249-11-5
Molecular Formula:C₂₉H₂₇FN₂O₃
Molecular Weight:470.543
Hs Code.:

Synonyms:4-(4-fluorophenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid 4-hydroxymethylbenzylamide

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Chemical Property of 4-(4-fluorophenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid 4-hydroxymethylbenzylamide

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Technology Process of 4-(4-fluorophenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid 4-hydroxymethylbenzylamide

There total 1 articles about 4-(4-fluorophenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid 4-hydroxymethylbenzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 855231-06-0
4-(4-fluoro-phenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid

: 39895-56-2
4-hydroxymethyl-benzylamine

: 855249-11-5
4-(4-fluorophenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid 4-hydroxymethylbenzylamide

Guidance literature:: 4-(4-fluoro-phenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid; With thionyl chloride; N,N-dimethyl-formamide; at 25 ℃; for 1.5h; Heating / reflux;

4-hydroxymethyl-benzylamine; With sodium carbonate; In water; ethyl acetate; at -10 - 25 ℃; for 14h;

Reference yield: 92.0%

: 855249-11-5
4-(4-fluorophenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid 4-hydroxymethylbenzylamide

: 3282-30-2
pivaloyl chloride

: 855249-12-6
2,2-dimethylpropionic acid 4-({[4-(4-fluorophenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carbonyl]amino}methyl)benzyl ester

Guidance literature:: 4-(4-fluorophenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid 4-hydroxymethylbenzylamide; pivaloyl chloride; With triethylamine; dmap; In dichloromethane; at 0 - 25 ℃; for 4h;

With hydrogenchloride; In diethyl ether; dichloromethane; water;

With sodium hydrogencarbonate; In diethyl ether; dichloromethane; water;