5-Chloro-6-ethylpyrimidin-4-ol

Base Information

• Chemical Name: 5-Chloro-6-ethylpyrimidin-4-ol
• CAS No.: 130129-58-7
• Molecular Formula: C6H7ClN2O
• Molecular Weight: 158.587
• Hs Code.: 2933599090
• Mol file: 130129-58-7.mol

Synonyms:4(1H)-Pyrimidinone,5-chloro-6-ethyl- (9CI);5-Chloro-6-ethyl-4-hydroxypyrimidine;

Chemical Property of 5-Chloro-6-ethylpyrimidin-4-ol

Chemical Property:

• Vapor Pressure: 0.093mmHg at 25°C
• Refractive Index: 1.59
• Boiling Point: 224.069 °C at 760 mmHg
• Flash Point: 89.314 °C
• PSA: 46.01000
• Density: 1.372 g/cm³
• LogP: 1.39800
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

5-Chloro-6-ethylpyrimidin-4-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Chloro-6-ethylpyrimidin-4-ol

There total 6 articles about 5-Chloro-6-ethylpyrimidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.6%

ethyl 2-chloro-3-oxopentanoate (24045-73-6) + formamidine acetic acid (3473-63-0) → 5-chloro-6-ethyl-4-hydroxypyrimidine (130129-58-7)

Guidance literature:

formamidine acetic acid; With sodium methylate; In methanol; at 0 - 5 ℃; for 1h; Inert atmosphere;

ethyl 2-chloro-3-oxopentanoate; In methanol; at 0 - 20 ℃; for 12h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;

Reference yield:

methyl 3-amino-2-chloro-2-pentenoate → 5-chloro-6-ethyl-4-hydroxypyrimidine (130129-58-7)

Guidance literature:

With sodium methylate; formamide; In methanol; water;

Reference yield:

methyl 2-chloro-3-oxopentanoate (114192-09-5) → 5-chloro-6-ethyl-4-hydroxypyrimidine (130129-58-7)

Guidance literature:

With sodium methylate; In methanol; water; formamide;

upstream raw materials:

6-ethyl-4(3H)-pyrimidinone

formamidine hydrochloride

methyl 2-chloro-3-oxopentanoate

ethyl 2-chloro-3-oxopentanoate

Downstream raw materials:

dimethyl-carbamic acid 4-[1-(5-chloro-6-ethyl-pyrimidin-4-ylamino)-ethyl]-phenyl ester