ethyl N-[4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-carbamoylphenyl]-N-[3-(3-cyanophenyl)-2-(E)-propenyl]sulfamoylacetate

Base Information

• Chemical Name: ethyl N-[4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-carbamoylphenyl]-N-[3-(3-cyanophenyl)-2-(E)-propenyl]sulfamoylacetate
• CAS No.: 337520-28-2
• Molecular Formula: C₃₁H₃₈N₄O₈S
• Molecular Weight: 626.731

Synonyms:ethyl N-[4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-carbamoylphenyl]-N-[3-(3-cyanophenyl)-2-(E)-propenyl]sulfamoylacetate

Chemical Property of ethyl N-[4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-carbamoylphenyl]-N-[3-(3-cyanophenyl)-2-(E)-propenyl]sulfamoylacetate

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Technology Process of ethyl N-[4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-carbamoylphenyl]-N-[3-(3-cyanophenyl)-2-(E)-propenyl]sulfamoylacetate

There total 2 articles about ethyl N-[4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-carbamoylphenyl]-N-[3-(3-cyanophenyl)-2-(E)-propenyl]sulfamoylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyl (N-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]-3-carbamoylphenyl}-sulfamoyl)acetate (337520-27-1) + 3-(3-cyanophenyl)-2-(E)-propen-1-ol (98116-50-8) → ethyl N-[4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-carbamoylphenyl]-N-[3-(3-cyanophenyl)-2-(E)-propenyl]sulfamoylacetate (337520-28-2)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In dichloromethane; at 0 - 20 ℃; for 8h;

Reference yield: 94.0%

ethyl (N-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]-3-carbamoylphenyl}-sulfamoyl)acetate (337520-27-1) + ethyl acetate (141-78-6) + diethylazodicarboxylate (1972-28-7,218603-74-8) + 3-(3-cyanophenyl)-2-(E)-propen-1-ol (98116-50-8) → ethyl N-[4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-carbamoylphenyl]-N-[3-(3-cyanophenyl)-2-(E)-propenyl]sulfamoylacetate (337520-28-2)

Guidance literature:

With triphenylphosphine; In hexane; dichloromethane;

Reference yield: 25.0%

ethyl N-[4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-carbamoylphenyl]-N-[3-(3-cyanophenyl)-2-(E)-propenyl]sulfamoylacetate (337520-28-2) + ammonium chloride + acetonitrile (75-05-8,26809-02-9) → ethyl N-[3-(3-amidinophenyl)-2-(E)-propenyl]-N-[3-carbamoyl-4-(piperidin-4-yloxy)phenyl]sulfamoylacetate dihydrochloride

Guidance literature:

With hydrogenchloride; In ammonium hydroxide; ethanol; dichloromethane; ethyl acetate;

upstream raw materials:

ethyl (N-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]-3-carbamoylphenyl}-sulfamoyl)acetate

3-(3-cyanophenyl)-2-(E)-propen-1-ol

ethyl acetate

diethylazodicarboxylate

Downstream raw materials:

ethyl N-[3-(3-amidinophenyl)-2-(E)-propenyl]-N-[3-carbamoyl-4-(piperidin-4-yloxy)phenyl]sulfamoylacetate

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