ethyl (N-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]-3-carbamoylphenyl}-sulfamoyl)acetate

Base Information

• Chemical Name: ethyl (N-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]-3-carbamoylphenyl}-sulfamoyl)acetate
• CAS No.: 337520-27-1
• Molecular Formula: C₂₁H₃₁N₃O₈S
• Molecular Weight: 485.558

Synonyms:ethyl (N-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]-3-carbamoylphenyl}-sulfamoyl)acetate

Chemical Property of ethyl (N-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]-3-carbamoylphenyl}-sulfamoyl)acetate

Chemical Property:

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Technology Process of ethyl (N-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]-3-carbamoylphenyl}-sulfamoyl)acetate

There total 2 articles about ethyl (N-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]-3-carbamoylphenyl}-sulfamoyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-carbamoylaniline (337520-26-0) + ethyl 2-(chlorosulfonyl)acetate (55896-93-0) → ethyl (N-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]-3-carbamoylphenyl}-sulfamoyl)acetate (337520-27-1)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 6h;

Reference yield: 53.0%

methanol (67-56-1) + 4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-carbamoylaniline (337520-26-0) + ethyl 2-(chlorosulfonyl)acetate (55896-93-0) → ethyl (N-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]-3-carbamoylphenyl}-sulfamoyl)acetate (337520-27-1)

Guidance literature:

With pyridine; In dichloromethane;

Reference yield: 100.0%

(Z)-3-(3-cyanophenyl)-2-propen-1-ol (337520-67-9) + ethyl (N-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]-3-carbamoylphenyl}-sulfamoyl)acetate (337520-27-1) → ethyl (N-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]-3-carbamoylphenyl}-N-[(Z)-3-(3-cyanophenyl)-2-fluoro-2-propenyl]sulfamoyl)acetate (470477-83-9)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In dichloromethane; at 20 ℃; for 2.5h;

DOI:10.1248/cpb.57.22

upstream raw materials:

4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-carbamoylaniline

ethyl 2-(chlorosulfonyl)acetate

methanol

Downstream raw materials:

ethyl N-[4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-carbamoylphenyl]-N-[3-(3-cyanophenyl)-2-(E)-propenyl]sulfamoylacetate

ethyl (N-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]-3-carbamoylphenyl}-N-[(Z)-3-(3-cyanophenyl)-2-fluoro-2-propenyl]sulfamoyl)acetate

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