2-(4-Hydroxypenyl)pyridine

Base Information

• Chemical Name: 2-(4-Hydroxypenyl)pyridine
• CAS No.: 51035-40-6
• Molecular Formula: C11H9NO
• Molecular Weight: 171.199
• Hs Code.: 2933399090
• Mol file: 51035-40-6.mol

Synonyms:Phenol,4-(2-pyridinyl)-;4-(2-Pyridinyl)phenol;4-(2-Pyridyl)phenol;p-(2-Pyridyl)phenol;

Chemical Property of 2-(4-Hydroxypenyl)pyridine

Chemical Property:

• Melting Point: 164-165 °C(Solv: benzene (71-43-2))
• Boiling Point: 185-188 °C(Press: 4 Torr)
• PKA: 8.72±0.13(Predicted)
• PSA: 33.12000
• Density: 1.169±0.06 g/cm3(Predicted)
• LogP: 2.45420
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-(Pyridin-2-yl)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-Hydroxypenyl)pyridine

There total 26 articles about 2-(4-Hydroxypenyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

p-Iodophenol (540-38-5) + pyridin-2-ylzinc(II) bromide → 4-pyridin-2-yl-phenol (51035-40-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; for 24h; Inert atmosphere; Reflux;

DOI:10.1016/j.tetlet.2009.09.160

Reference yield: 90.0%

4-(2-pyridinyl)anisole (5957-90-4) → 4-pyridin-2-yl-phenol (51035-40-6)

Guidance literature:

With hydrogen bromide; at 130 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.jorganchem.2020.121644

Reference yield: 88.0%

Trimethylenediamine (109-76-2,54018-94-9) + 4-Hydroxyacetophenone (99-93-4) → 4-pyridin-2-yl-phenol (51035-40-6)

Guidance literature:

With hydrogenchloride; iodine; oxygen; In dimethyl sulfoxide; at 80 ℃; for 4h;

DOI:10.1039/c5cc08498a

upstream raw materials:

pyridine

[1,4]benzoquinone monosemicarbazone

4-(pyridin-2-yl)aniline

4-(2-pyridinyl)anisole

Downstream raw materials:

methyl [4-(pyridin-2-yl)phenoxy]acetate

4-(2-pyridinyl)anisole

Refernces

• 1、 Ward, Jonathan S.,De Palo, Alice,Aucott, Benjamin J.,Moir, James W. B.,Lynam, Jason M.,Fairlamb, Ian J. S.. "A biotin-conjugated photo-Activated CO-releasing molecule (biotinCORM): Efficient CO-release from an avidin-biotinCORM protein adduct". . p. 16233 - 16241. Retrieved 2019.
• 2、 -. "COMPOUNDS AND METHODS FOR TREATING OXALATE-RELATED DISEASES". Paragraph 0283; 0288. . Retrieved 2019/09/12.