acetic acid 4-[1-(3-iodopropane-1-sulfonyloxy)-2,2,2-trifluoroethyl]phenyl ester

Base Information

• Chemical Name: acetic acid 4-[1-(3-iodopropane-1-sulfonyloxy)-2,2,2-trifluoroethyl]phenyl ester
• CAS No.: 1345614-63-2
• Molecular Formula: C₁₃H₁₄F₃IO₅S
• Molecular Weight: 466.217

Synonyms:acetic acid 4-[1-(3-iodopropane-1-sulfonyloxy)-2,2,2-trifluoroethyl]phenyl ester

Chemical Property of acetic acid 4-[1-(3-iodopropane-1-sulfonyloxy)-2,2,2-trifluoroethyl]phenyl ester

Chemical Property:

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Technology Process of acetic acid 4-[1-(3-iodopropane-1-sulfonyloxy)-2,2,2-trifluoroethyl]phenyl ester

There total 2 articles about acetic acid 4-[1-(3-iodopropane-1-sulfonyloxy)-2,2,2-trifluoroethyl]phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

acetic acid 4-[1-(3-chloropropane-1-sulfonyloxy)-2,2,2-trifluoroethyl]phenyl ester (1345614-61-0) → acetic acid 4-[1-(3-iodopropane-1-sulfonyloxy)-2,2,2-trifluoroethyl]phenyl ester (1345614-63-2)

Guidance literature:

With sodium iodide; In acetone; for 17h; Reflux;

DOI:10.1021/ol202619f

Reference yield:

acetic acid 4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl ester (1279691-41-6) → acetic acid 4-[1-(3-iodopropane-1-sulfonyloxy)-2,2,2-trifluoroethyl]phenyl ester (1345614-63-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / 0 °C

2: sodium iodide / acetone / 17 h / Reflux

With triethylamine; sodium iodide; In dichloromethane; acetone;

DOI:10.1021/ol202619f

Reference yield: 68.0%

7-(tert-butyldimethylsilanyloxy)-1,2,3,4-tetrahydroquinoline (1233524-42-9) + acetic acid 4-[1-(3-iodopropane-1-sulfonyloxy)-2,2,2-trifluoroethyl]phenyl ester (1345614-63-2) → acetic acid 4-(1{3-[7-(tert-butyldimethylsilanyloxy)-3,4-dihydro-2H-quinolin-1-yl]propane-1-sulfonyloxy}-2,2,2-trifluoroethyl)phenyl ester (1345614-77-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 65 ℃;

DOI:10.1021/ol202619f

upstream raw materials:

acetic acid 4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl ester

acetic acid 4-[1-(3-chloropropane-1-sulfonyloxy)-2,2,2-trifluoroethyl]phenyl ester

Downstream raw materials:

acetic acid 4-{2,2,2-trifluuoro-1-[3-(7-methoxy-3,4-dihydro-2H-quinolin-1-yl)propane-1-sulfonyloxy]ethyl}phenyl ester

acetic acid 4-(2,2,2-trifluoro-1-{3-[7-methoxy-6-(4-nitrophenylazo)-3,4-dihydro-2H-quinolin-1-yl]propane-1-sulfonyloxy}ethyl)phenyl ester

11-{3-[1-(4-acetoxyphenyl)-2,2,2-trifluoroethoxysulfonyl]propyl}-3,4,8,9,10,11-hexahydro-2H-13-oxa-6,11-diaza-1-azonia-pentacene trifluoroacetate

1,11-bis{3-[1-(4-acetoxyphenyl)-2,2,2-trifluoroethoxysulfonyl]propyl}-3,4,8,9,10,11-hexahydro-2H-13-oxa-6,11-diaza-1-azonia-pentacene tetrafluoroborate

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