ethyl 4-[3-(hydroxymethyl)-5-(4-methylthiophenyl)pyrazolyl]piperidine-1-carboxylate

Base Information

Chemical Name:ethyl 4-[3-(hydroxymethyl)-5-(4-methylthiophenyl)pyrazolyl]piperidine-1-carboxylate
CAS No.:693287-97-7
Molecular Formula:C₁₉H₂₅N₃O₃S
Molecular Weight:375.492
Hs Code.:

Synonyms:ethyl 4-[3-(hydroxymethyl)-5-(4-methylthiophenyl)pyrazolyl]piperidine-1-carboxylate

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Chemical Property of ethyl 4-[3-(hydroxymethyl)-5-(4-methylthiophenyl)pyrazolyl]piperidine-1-carboxylate

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Technology Process of ethyl 4-[3-(hydroxymethyl)-5-(4-methylthiophenyl)pyrazolyl]piperidine-1-carboxylate

There total 7 articles about ethyl 4-[3-(hydroxymethyl)-5-(4-methylthiophenyl)pyrazolyl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 693287-96-6
methyl 1-[1-(ethoxycarbonyl)(4-piperidyl)]-5-(4-methylthiophenyl)pyrazole-3-carboxylate

: 693287-97-7
ethyl 4-[3-(hydroxymethyl)-5-(4-methylthiophenyl)pyrazolyl]piperidine-1-carboxylate

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm030276s

Reference yield:

: 1778-09-2
4-(Methylthio)acetophenone

: 693287-97-7
ethyl 4-[3-(hydroxymethyl)-5-(4-methylthiophenyl)pyrazolyl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / sodium methoxide / toluene / 2 h / 20 °C

2: 62 percent / trifluoroacetic acid / methanol / 70 °C

3: 35 percent / LiAlH₄ / tetrahydrofuran / 20 °C

With lithium aluminium tetrahydride; sodium methylate; trifluoroacetic acid; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm030276s

Reference yield:

: 29976-53-2
N-ethoxycarbonyl-4-piperidone

: 693287-97-7
ethyl 4-[3-(hydroxymethyl)-5-(4-methylthiophenyl)pyrazolyl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / methanol / 20 °C

2: 100 percent / sodium cyanoborohydride; aq. acetic acid / 20 °C

3: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 20 °C

4: 62 percent / trifluoroacetic acid / methanol / 70 °C

5: 35 percent / LiAlH₄ / tetrahydrofuran / 20 °C

With lithium aluminium tetrahydride; sodium cyanoborohydride; acetic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm030276s