2,3-bis-O-tert-butyldimethylsilyl-1,4-bis-O-methanesulfonyl-5-O-triphenylmethyl-L-arabinitol

Base Information

Chemical Name:2,3-bis-O-tert-butyldimethylsilyl-1,4-bis-O-methanesulfonyl-5-O-triphenylmethyl-L-arabinitol
CAS No.:443127-33-1
Molecular Formula:C₃₈H₅₈O₉S₂Si₂
Molecular Weight:779.176
Hs Code.:

Synonyms:2,3-bis-O-tert-butyldimethylsilyl-1,4-bis-O-methanesulfonyl-5-O-triphenylmethyl-L-arabinitol

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Chemical Property of 2,3-bis-O-tert-butyldimethylsilyl-1,4-bis-O-methanesulfonyl-5-O-triphenylmethyl-L-arabinitol

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Technology Process of 2,3-bis-O-tert-butyldimethylsilyl-1,4-bis-O-methanesulfonyl-5-O-triphenylmethyl-L-arabinitol

There total 7 articles about 2,3-bis-O-tert-butyldimethylsilyl-1,4-bis-O-methanesulfonyl-5-O-triphenylmethyl-L-arabinitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 124-63-0
methanesulfonyl chloride

: 443127-31-9
2,3-bis-O-tert-butyldimethylsilyl-5-O-triphenylmethyl-L-arabinitol

: (2S,3S,4S)-3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-2-trityloxymethyl-tetrahydro-furan

: 443127-33-1
2,3-bis-O-tert-butyldimethylsilyl-1,4-bis-O-methanesulfonyl-5-O-triphenylmethyl-L-arabinitol

Guidance literature:: With pyridine; dmap; at 20 ℃; for 14h;
DOI:10.1021/jo025538x

Reference yield:

: 76-83-5
trityl chloride

: 443127-33-1
2,3-bis-O-tert-butyldimethylsilyl-1,4-bis-O-methanesulfonyl-5-O-triphenylmethyl-L-arabinitol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 66 percent / pyridine; DMAP / 16 h / 70 °C

2.1: 88 percent / imidazole / dimethylformamide / 48 h / 20 °C

3.1: LiBH₄ / tetrahydrofuran

3.2: pyridine; DMAP

With pyridine; 1H-imidazole; dmap; lithium borohydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo025538x

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 443127-33-1
2,3-bis-O-tert-butyldimethylsilyl-1,4-bis-O-methanesulfonyl-5-O-triphenylmethyl-L-arabinitol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 88 percent / imidazole / dimethylformamide / 48 h / 20 °C

2.1: LiBH₄ / tetrahydrofuran

2.2: pyridine; DMAP

With 1H-imidazole; lithium borohydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo025538x