Technology Process of 1-(5-nitro-1-trityl-1H-indazol-3-yl)-propynone
There total 6 articles about 1-(5-nitro-1-trityl-1H-indazol-3-yl)-propynone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
trimethylsilylacetylene;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran; toluene;
at -20 - 0 ℃;
for 0.5h;
5-nitro-1-trityl-1H-indazole-3-carboxylic acid methoxy-methyl-amide;
In
tetrahydrofuran; toluene;
at -5 - 20 ℃;
for 1.5h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: thionyl chloride / 0 °C / Heating / reflux
2.1: sodium hydride / tetrahydrofuran; dichloromethane / 0 °C
2.2: 0 - 60 °C
3.1: lithium hydroxide; water / tetrahydrofuran / 20 °C
4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C
5.1: lithium hexamethyldisilazane / tetrahydrofuran; toluene / 0.5 h / -20 - 0 °C
5.2: 1.5 h / -5 - 20 °C
With
lithium hydroxide; thionyl chloride; water; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sulfuric acid; potassium nitrate / 4 h / 0 - 20 °C
2.1: thionyl chloride / 0 °C / Heating / reflux
3.1: sodium hydride / tetrahydrofuran; dichloromethane / 0 °C
3.2: 0 - 60 °C
4.1: lithium hydroxide; water / tetrahydrofuran / 20 °C
5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C
6.1: lithium hexamethyldisilazane / tetrahydrofuran; toluene / 0.5 h / -20 - 0 °C
6.2: 1.5 h / -5 - 20 °C
With
lithium hydroxide; thionyl chloride; sulfuric acid; water; sodium hydride; potassium nitrate; N-ethyl-N,N-diisopropylamine; HATU; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
