3-(1-methyl-1H-pyrazol-3-yl)-5-nitro-1-trityl-1H-indazole

Base Information

Chemical Name:3-(1-methyl-1H-pyrazol-3-yl)-5-nitro-1-trityl-1H-indazole
CAS No.:1093064-69-7
Molecular Formula:C₃₀H₂₃N₅O₂
Molecular Weight:485.545
Hs Code.:

Synonyms:3-(1-methyl-1H-pyrazol-3-yl)-5-nitro-1-trityl-1H-indazole

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Chemical Property of 3-(1-methyl-1H-pyrazol-3-yl)-5-nitro-1-trityl-1H-indazole

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Technology Process of 3-(1-methyl-1H-pyrazol-3-yl)-5-nitro-1-trityl-1H-indazole

There total 7 articles about 3-(1-methyl-1H-pyrazol-3-yl)-5-nitro-1-trityl-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1093064-19-7
1-(5-nitro-1-trityl-1H-indazol-3-yl)-propynone

: 7339-53-9,55330-60-4,88216-08-4
methyl hydrazine hydrochloride

: 1093064-69-7
3-(1-methyl-1H-pyrazol-3-yl)-5-nitro-1-trityl-1H-indazole

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 120 ℃; for 0.833333h; Microwave irradiation;

Reference yield:

: 78155-76-7
5-nitro-1H-indazole-3-carboxylic acid

: 1093064-69-7
3-(1-methyl-1H-pyrazol-3-yl)-5-nitro-1-trityl-1H-indazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 0 °C / Heating / reflux

2.1: sodium hydride / tetrahydrofuran; dichloromethane / 0 °C

2.2: 0 - 60 °C

3.1: lithium hydroxide; water / tetrahydrofuran / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran; toluene / 0.5 h / -20 - 0 °C

5.2: 1.5 h / -5 - 20 °C

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.83 h / 120 °C / Microwave irradiation

With lithium hydroxide; thionyl chloride; water; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; HATU; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 4498-67-3
1H-Indazole-3-carboxylic acid

: 1093064-69-7
3-(1-methyl-1H-pyrazol-3-yl)-5-nitro-1-trityl-1H-indazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid; potassium nitrate / 4 h / 0 - 20 °C

2.1: thionyl chloride / 0 °C / Heating / reflux

3.1: sodium hydride / tetrahydrofuran; dichloromethane / 0 °C

3.2: 0 - 60 °C

4.1: lithium hydroxide; water / tetrahydrofuran / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran; toluene / 0.5 h / -20 - 0 °C

6.2: 1.5 h / -5 - 20 °C

7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.83 h / 120 °C / Microwave irradiation

With lithium hydroxide; thionyl chloride; sulfuric acid; water; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium nitrate; N-ethyl-N,N-diisopropylamine; HATU; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;