N-{4-methyl-2-[4-(2-nitro-phenylamino)-piperidin-1-yl]-phenyl}-acetamide

Base Information

Chemical Name:N-{4-methyl-2-[4-(2-nitro-phenylamino)-piperidin-1-yl]-phenyl}-acetamide
CAS No.:1352721-47-1
Molecular Formula:C₂₀H₂₄N₄O₃
Molecular Weight:368.436
Hs Code.:

Synonyms:N-{4-methyl-2-[4-(2-nitro-phenylamino)-piperidin-1-yl]-phenyl}-acetamide

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Chemical Property of N-{4-methyl-2-[4-(2-nitro-phenylamino)-piperidin-1-yl]-phenyl}-acetamide

Chemical Property:

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Technology Process of N-{4-methyl-2-[4-(2-nitro-phenylamino)-piperidin-1-yl]-phenyl}-acetamide

There total 6 articles about N-{4-methyl-2-[4-(2-nitro-phenylamino)-piperidin-1-yl]-phenyl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1352721-48-2
N-[2-(4-amino-piperidin-1-yl)-4-methyl-phenyl]-acetamide

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1352721-47-1
N-{4-methyl-2-[4-(2-nitro-phenylamino)-piperidin-1-yl]-phenyl}-acetamide

Guidance literature:: N-[2-(4-amino-piperidin-1-yl)-4-methyl-phenyl]-acetamide; ortho-nitrofluorobenzene; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 150 ℃; for 2.25h; Sealed vessel;

With hydrogenchloride; In water;

Reference yield:

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 1352721-47-1
N-{4-methyl-2-[4-(2-nitro-phenylamino)-piperidin-1-yl]-phenyl}-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / acetonitrile / 20 h / 20 - 50 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 1.5 h / 20 °C / 760.05 Torr

3: triethylamine / ethyl acetate / 1 h / 80 °C

4: trifluoroacetic acid / dichloromethane; water / 1 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / acetonitrile / 2.25 h / 150 °C / Sealed vessel

With hydrogen; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; water; ethyl acetate; acetonitrile;

Reference yield:

: 446-34-4
2-fluoro-4-methyl-1-nitrobenzene

: 1352721-47-1
N-{4-methyl-2-[4-(2-nitro-phenylamino)-piperidin-1-yl]-phenyl}-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / acetonitrile / 20 h / 20 - 50 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 1.5 h / 20 °C / 760.05 Torr

3: triethylamine / ethyl acetate / 1 h / 80 °C

4: trifluoroacetic acid / dichloromethane; water / 1 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / acetonitrile / 2.25 h / 150 °C / Sealed vessel

With hydrogen; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; water; ethyl acetate; acetonitrile;