Oleanolic acid benzoate

Base Information

• Chemical Name: Oleanolic acid benzoate
• CAS No.: 6153-31-7
• Molecular Formula: C37H52O4
• Molecular Weight: 560.817
• Mol file: 6153-31-7.mol

Synonyms:Olean-12-en-28-oicacid, 3b-hydroxy-, benzoate (8CI);Benzoyloleanolic acid;Oleanolic acid benzoate;(3β)-3-(Benzoyloxy)olean-12-en-28-oic acid;olean-12-en-28-oic acid, 3-(benzoyloxy)-, (3β)-;

Chemical Property of Oleanolic acid benzoate

Chemical Property:

• Refractive Index: 1.573
• Boiling Point: 630.7 °C at 760 mmHg
• Flash Point: 188.4 °C
• PSA: 63.60000
• Density: 1.3 g/cm³
• LogP: 9.09830

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Oleanolic acid benzoate

There total 3 articles about Oleanolic acid benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

Oleanolic acid (508-02-1) + benzoyl chloride (98-88-4) → (3β)-3-(benzoyloxy)olean-12-en-28-oic acid (6153-31-7)

Guidance literature:

Oleanolic acid; With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

benzoyl chloride; In dichloromethane; at 30 ℃; Temperature; Microwave irradiation;

DOI:10.1016/j.ejmech.2014.09.036

Reference yield: 69.0%

Oleanolic acid (508-02-1) + benzoic acid anhydride (93-97-0) → (3β)-3-(benzoyloxy)olean-12-en-28-oic acid (6153-31-7)

Guidance literature:

With pyridine; at 20 ℃; for 24h;

DOI:10.1016/j.ejmech.2013.12.049

Reference yield:

C37H51O4Pol → (3β)-3-(benzoyloxy)olean-12-en-28-oic acid (6153-31-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.ejmech.2013.12.049

upstream raw materials:

Oleanolic acid

benzoyl chloride

benzoic acid anhydride

Downstream raw materials:

Benzoic acid (4aS,6aS,6bR,8aR,10S,12aS,12bR)-10-(tert-butyl-dimethyl-silanyloxy)-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b-hexadecahydro-2H-picen-4a-ylmethyl ester

C₃₇H₅₂O₂

erythrodiol

Oleanolic acid

Refernces

• 1、 Parra, Andres,Martin-Fonseca, Samuel,Rivas, Francisco,Reyes-Zurita, Fernando J.,Medina-O'Donnell, Marta,Martinez, Antonio,Garcia-Granados, Andres,Lupia?ez, Jose A.,Albericio, Fernando. "Semi-synthesis of acylated triterpenes from olive-oil industry wastes for the development of anticancer and anti-HIV agents". . p. 278 - 301. Retrieved 2014/02/14.