phenylmethanamine-1,1-d₂-amine hydrochloride

Base Information

• Chemical Name: phenylmethanamine-1,1-d₂-amine hydrochloride
• CAS No.: 92204-13-2
• Molecular Formula: C₇H₉N*ClH
• Molecular Weight: 145.6
• Mol file: 92204-13-2.mol

Synonyms:phenylmethanamine-1,1-d₂-amine hydrochloride

Chemical Property of phenylmethanamine-1,1-d₂-amine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenylmethanamine-1,1-d₂-amine hydrochloride

There total 3 articles about phenylmethanamine-1,1-d₂-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

benzonitrile (100-47-0) → phenylmethanamine-1,1-d2-amine hydrochloride (92204-13-2)

Guidance literature:

With 10% Pd/C; hydrogen; water-d2; hydrogen chloride; In methanol; at 20 ℃; for 24h; chemoselective reaction;

DOI:10.1002/chem.200701245

Reference yield: 90.0%

benzamide (55-21-0,27208-38-4) → phenylmethanamine-1,1-d2-amine hydrochloride (92204-13-2)

Guidance literature:

benzamide; With phenylsilane-d3; C₃₆H₄₈F₆N₆NiO₅S₂; In toluene; at 110 ℃; for 12h; Inert atmosphere; Schlenk technique;

With hydrogenchloride; In diethyl ether;

DOI:10.1039/d1cc03537a

Reference yield:

1,1-dideuteriobenzylamine (15185-02-1) → phenylmethanamine-1,1-d2-amine hydrochloride (92204-13-2)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja205629b

upstream raw materials:

benzonitrile

1,1-dideuteriobenzylamine

benzamide

Downstream raw materials:

Benzaldehyde-d

Refernces

• 1、 -. "Alpha, alpha-dideuterated amine compound, deuterated medicine and preparation method thereof". Paragraph 0020; 0021. . Retrieved 2021/01/30.
• 2、 MacMillar, Susanna,Edmondson, Dale E.,Matsson, Olle. "Nitrogen kinetic isotope effects for the monoamine oxidase B-catalyzed oxidation of benzylamine and (1,1-2H2)benzylamine: Nitrogen rehybridization and CH bond cleavage are not concerted". supporting information; experimental part. p. 12319 - 12321. Retrieved 2011/10/09.