N-(2-(4-bromo-1H-indol-3-yl)ethyl)-N-(4-methoxybenzyl)-4,4-dimethylpent-2-ynamide

Base Information

Chemical Name:N-(2-(4-bromo-1H-indol-3-yl)ethyl)-N-(4-methoxybenzyl)-4,4-dimethylpent-2-ynamide
CAS No.:1294437-49-2
Molecular Formula:C₂₅H₂₇BrN₂O₂
Molecular Weight:467.406
Hs Code.:

Synonyms:N-(2-(4-bromo-1H-indol-3-yl)ethyl)-N-(4-methoxybenzyl)-4,4-dimethylpent-2-ynamide

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Chemical Property of N-(2-(4-bromo-1H-indol-3-yl)ethyl)-N-(4-methoxybenzyl)-4,4-dimethylpent-2-ynamide

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Technology Process of N-(2-(4-bromo-1H-indol-3-yl)ethyl)-N-(4-methoxybenzyl)-4,4-dimethylpent-2-ynamide

There total 4 articles about N-(2-(4-bromo-1H-indol-3-yl)ethyl)-N-(4-methoxybenzyl)-4,4-dimethylpent-2-ynamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 52418-50-5
4,4-dimethyl-2-pentynoic acid

: 1294437-40-3
2-(4-bromo-1H-indol-3-yl)-N-(4-methoxybenzyl)ethanamine

: 1294437-49-2
N-(2-(4-bromo-1H-indol-3-yl)ethyl)-N-(4-methoxybenzyl)-4,4-dimethylpent-2-ynamide

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 25 ℃;
DOI:10.1002/ejoc.201001669

Reference yield:

: 2-(4-bromo-1H-indol-3-yl)-N-(4-methoxybenzylidene)ethanamine

: 1294437-49-2
N-(2-(4-bromo-1H-indol-3-yl)ethyl)-N-(4-methoxybenzyl)-4,4-dimethylpent-2-ynamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / 25 °C

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 25 °C

With dmap; sodium tetrahydroborate; dicyclohexyl-carbodiimide; In ethanol; dichloromethane;
DOI:10.1002/ejoc.201001669

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1294437-49-2
N-(2-(4-bromo-1H-indol-3-yl)ethyl)-N-(4-methoxybenzyl)-4,4-dimethylpent-2-ynamide

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / 3 h / Reflux

2: sodium tetrahydroborate / ethanol / 25 °C

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 25 °C

With dmap; sodium tetrahydroborate; dicyclohexyl-carbodiimide; In ethanol; dichloromethane; toluene;
DOI:10.1002/ejoc.201001669