(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 4-bromobenzenesulfonate ester

Base Information

Chemical Name:(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 4-bromobenzenesulfonate ester
CAS No.:886021-96-1
Molecular Formula:C₁₆H₂₃BrO₃S
Molecular Weight:375.327
Hs Code.:

Synonyms:(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 4-bromobenzenesulfonate ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 4-bromobenzenesulfonate ester

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Technology Process of (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 4-bromobenzenesulfonate ester

There total 2 articles about (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 4-bromobenzenesulfonate ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 848649-38-7
4-bromobenzenesulfonic acid pentafluorophenyl ester

: 2216-51-5
(-)-menthol

: 886021-96-1
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 4-bromobenzenesulfonate ester

Guidance literature:: (-)-menthol; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 1h; Inert atmosphere;

4-bromobenzenesulfonic acid pentafluorophenyl ester; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/acs.orglett.8b02445

Reference yield:

: 5467-74-3
4-Bromophenylboronic acid

: 886021-96-1
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 4-bromobenzenesulfonate ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,4-diazabicyclo [2.2.2] octane-1,4-diium-1,4-disulfinate; tetrabutylammomium bromide; palladium diacetate / methanol / 1 h / 80 °C / Sealed tube

1.2: 18 h / 20 °C / Molecular sieve; Sealed tube

2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2.2: 1 h / 0 - 20 °C / Inert atmosphere

With n-butyllithium; 1,4-diazabicyclo [2.2.2] octane-1,4-diium-1,4-disulfinate; tetrabutylammomium bromide; palladium diacetate; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/acs.orglett.8b02445