(2''S)-N-{1-[(1S,2S)-2-(2',6'-dimethoxy-4'-pentylphenyl)-4-methylcyclohex-3-en-1-yl]ethylidene}-2''-(methoxymethyl)-pyrrolidin-1''-amine

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Chemical Name:(2''S)-N-{1-[(1S,2S)-2-(2',6'-dimethoxy-4'-pentylphenyl)-4-methylcyclohex-3-en-1-yl]ethylidene}-2''-(methoxymethyl)-pyrrolidin-1''-amine
CAS No.:1310045-82-9
Molecular Formula:C₂₈H₄₄N₂O₃
Molecular Weight:456.669
Hs Code.:

Synonyms:(2''S)-N-{1-[(1S,2S)-2-(2',6'-dimethoxy-4'-pentylphenyl)-4-methylcyclohex-3-en-1-yl]ethylidene}-2''-(methoxymethyl)-pyrrolidin-1''-amine

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Chemical Property of (2''S)-N-{1-[(1S,2S)-2-(2',6'-dimethoxy-4'-pentylphenyl)-4-methylcyclohex-3-en-1-yl]ethylidene}-2''-(methoxymethyl)-pyrrolidin-1''-amine

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Technology Process of (2''S)-N-{1-[(1S,2S)-2-(2',6'-dimethoxy-4'-pentylphenyl)-4-methylcyclohex-3-en-1-yl]ethylidene}-2''-(methoxymethyl)-pyrrolidin-1''-amine

There total 5 articles about (2''S)-N-{1-[(1S,2S)-2-(2',6'-dimethoxy-4'-pentylphenyl)-4-methylcyclohex-3-en-1-yl]ethylidene}-2''-(methoxymethyl)-pyrrolidin-1''-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: rel-1-((1R,2R)-2-(2',6'-dimethoxy-4'-pentylphenyl)-4-methylcyclohex-3-enyl)ethanone

: 59983-39-0,187035-29-6
(S)-1-amino-2-(methoxymethyl)pyrrolidine

: 1310045-80-7
(2''S)-N-{(1E)-1-[(1R,2R)-2-(2',6'-dimethoxy-4'-pentylphenyl)-4-methylcyclohex-3-en-1-yl]ethylidene}-2''-(methoxymethyl)pyrrolidin-1''-amine

: 1310045-82-9
(2''S)-N-{1-[(1S,2S)-2-(2',6'-dimethoxy-4'-pentylphenyl)-4-methylcyclohex-3-en-1-yl]ethylidene}-2''-(methoxymethyl)-pyrrolidin-1''-amine

Guidance literature:: With toluene-4-sulfonic acid; In n-heptane; at 100 ℃; for 47h;
DOI:10.1021/jo200796b

Reference yield:

: 3410-84-2
2,6-dimethoxy-4-pentylbenzaldehyde

: 1310045-82-9
(2''S)-N-{1-[(1S,2S)-2-(2',6'-dimethoxy-4'-pentylphenyl)-4-methylcyclohex-3-en-1-yl]ethylidene}-2''-(methoxymethyl)-pyrrolidin-1''-amine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / water

2: tetrahydrofuran

3: hydroquinone / ethanol / 36 h / 21 °C / 6750680 Torr

4: sodium methylate / methanol / 22 h / 22 °C / Inert atmosphere

5: toluene-4-sulfonic acid / n-heptane / 47 h / 100 °C

With sodium methylate; toluene-4-sulfonic acid; hydroquinone; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; n-heptane; water; 1: Aldol condensation / 2: Wittig reaction / 3: Diels-Alder reaction;
DOI:10.1021/jo200796b

Reference yield:

: 7663-54-9
2',6'-dimethoxy-1'-((E)-3-methylbuta-1,3-dienyl)-4'-pentylbenzene

: 1310045-82-9
(2''S)-N-{1-[(1S,2S)-2-(2',6'-dimethoxy-4'-pentylphenyl)-4-methylcyclohex-3-en-1-yl]ethylidene}-2''-(methoxymethyl)-pyrrolidin-1''-amine

Guidance literature:: Multi-step reaction with 3 steps

1: hydroquinone / ethanol / 36 h / 21 °C / 6750680 Torr

2: sodium methylate / methanol / 22 h / 22 °C / Inert atmosphere

3: toluene-4-sulfonic acid / n-heptane / 47 h / 100 °C

With sodium methylate; toluene-4-sulfonic acid; hydroquinone; In methanol; ethanol; n-heptane; 1: Diels-Alder reaction;
DOI:10.1021/jo200796b