Technology Process of N-(2-((4,6-dimorpholino-1,3,5-triazin-2-yl)amino)-4-methoxyphenyl)-2,2-difluoroacetamide
There total 3 articles about N-(2-((4,6-dimorpholino-1,3,5-triazin-2-yl)amino)-4-methoxyphenyl)-2,2-difluoroacetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
difluoroacetyl chloride; N1-(4,6-dimorpholino-1,3,5-triazin-2-yl)-5-methoxybenzene-1,2-diamine;
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
for 0.5h;
With
triethylamine;
In
ethyl acetate;
regioselective reaction;
DOI:10.1016/j.bmcl.2012.11.076
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tin(II) chloride dihdyrate / ethyl acetate / 2 h / 70 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C
With
tin(II) chloride dihdyrate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2012.11.076
- Guidance literature:
-
Multi-step reaction with 3 steps
1: caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.75 h / 150 °C / Sealed tube; Microwave irradiation
2: tin(II) chloride dihdyrate / ethyl acetate / 2 h / 70 °C / Inert atmosphere
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C
With
tin(II) chloride dihdyrate; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
1,4-dioxane; dichloromethane; ethyl acetate;
1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmcl.2012.11.076
