N-(2-((4,6-dimorpholino-1,3,5-triazin-2-yl)amino)-4-methoxyphenyl)-2,2-difluoroacetamide

Base Information

Chemical Name:N-(2-((4,6-dimorpholino-1,3,5-triazin-2-yl)amino)-4-methoxyphenyl)-2,2-difluoroacetamide
CAS No.:1421518-25-3
Molecular Formula:C₂₀H₂₅F₂N₇O₄
Molecular Weight:465.46
Hs Code.:

Synonyms:N-(2-((4,6-dimorpholino-1,3,5-triazin-2-yl)amino)-4-methoxyphenyl)-2,2-difluoroacetamide

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Chemical Property of N-(2-((4,6-dimorpholino-1,3,5-triazin-2-yl)amino)-4-methoxyphenyl)-2,2-difluoroacetamide

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Technology Process of N-(2-((4,6-dimorpholino-1,3,5-triazin-2-yl)amino)-4-methoxyphenyl)-2,2-difluoroacetamide

There total 3 articles about N-(2-((4,6-dimorpholino-1,3,5-triazin-2-yl)amino)-4-methoxyphenyl)-2,2-difluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 381-72-6
difluoroacetyl chloride

: 1421518-23-1
N₁-(4,6-dimorpholino-1,3,5-triazin-2-yl)-5-methoxybenzene-1,2-diamine

: 1421518-25-3
N-(2-((4,6-dimorpholino-1,3,5-triazin-2-yl)amino)-4-methoxyphenyl)-2,2-difluoroacetamide

Guidance literature:: difluoroacetyl chloride; N₁-(4,6-dimorpholino-1,3,5-triazin-2-yl)-5-methoxybenzene-1,2-diamine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

With triethylamine; In ethyl acetate; regioselective reaction;
DOI:10.1016/j.bmcl.2012.11.076

Reference yield:

: 1421518-21-9
N-(5-methoxy-2-nitrophenyl)-4,6-dimorpholino-1,3,5-triazin-2-amine

: 1421518-25-3
N-(2-((4,6-dimorpholino-1,3,5-triazin-2-yl)amino)-4-methoxyphenyl)-2,2-difluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: tin(II) chloride dihdyrate / ethyl acetate / 2 h / 70 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

With tin(II) chloride dihdyrate; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2012.11.076

Reference yield:

: 7597-22-0
2-chloro-4,6-di-morpholin-4-yl-[1,3,5]triazine

: 1421518-25-3
N-(2-((4,6-dimorpholino-1,3,5-triazin-2-yl)amino)-4-methoxyphenyl)-2,2-difluoroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.75 h / 150 °C / Sealed tube; Microwave irradiation

2: tin(II) chloride dihdyrate / ethyl acetate / 2 h / 70 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

With tin(II) chloride dihdyrate; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; ethyl acetate; 1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmcl.2012.11.076