methyl N-(N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-[(7-cyano-2-naphthyl)methyl]sulfamoyl)-N-ethoxycarbonyl glycinate

Base Information

Chemical Name:methyl N-(N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-[(7-cyano-2-naphthyl)methyl]sulfamoyl)-N-ethoxycarbonyl glycinate
CAS No.:454437-50-4
Molecular Formula:C₃₄H₄₀N₄O₉S
Molecular Weight:680.779
Hs Code.:

Synonyms:methyl N-(N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-[(7-cyano-2-naphthyl)methyl]sulfamoyl)-N-ethoxycarbonyl glycinate

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Chemical Property of methyl N-(N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-[(7-cyano-2-naphthyl)methyl]sulfamoyl)-N-ethoxycarbonyl glycinate

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Technology Process of methyl N-(N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-[(7-cyano-2-naphthyl)methyl]sulfamoyl)-N-ethoxycarbonyl glycinate

There total 6 articles about methyl N-(N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-[(7-cyano-2-naphthyl)methyl]sulfamoyl)-N-ethoxycarbonyl glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 96-32-2
bromoacetic acid methyl ester

: 179756-26-4
ethyl N-(N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-[(7-cyano-2-naphthyl)methyl]sulfamoyl)carbamate

: 454437-50-4
methyl N-(N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-[(7-cyano-2-naphthyl)methyl]sulfamoyl)-N-ethoxycarbonyl glycinate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1016/S0968-0896(01)00418-7

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 454437-50-4
methyl N-(N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-[(7-cyano-2-naphthyl)methyl]sulfamoyl)-N-ethoxycarbonyl glycinate

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / Ph₃P; DEAD / tetrahydrofuran / 21 h / 20 °C

2: 98 percent / H₂ / 10 percent Pd/C / ethanol / 15 h / 20 °C

3: 79 percent / NaB(OAc)3H / CH₂Cl₂; acetic acid / 0.75 h / 20 °C

4: 72 percent / pyridine / 15 h / 3 °C

5: 98 percent / K₂CO₃ / dimethylformamide / 18 h / 20 °C

With pyridine; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; 1: Mitsunobu condensation;
DOI:10.1016/S0968-0896(01)00418-7

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 454437-50-4
methyl N-(N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-[(7-cyano-2-naphthyl)methyl]sulfamoyl)-N-ethoxycarbonyl glycinate

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / Ph₃P; DEAD / tetrahydrofuran / 21 h / 20 °C

2: 98 percent / H₂ / 10 percent Pd/C / ethanol / 15 h / 20 °C

3: 79 percent / NaB(OAc)3H / CH₂Cl₂; acetic acid / 0.75 h / 20 °C

4: 72 percent / pyridine / 15 h / 3 °C

5: 98 percent / K₂CO₃ / dimethylformamide / 18 h / 20 °C

With pyridine; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; 1: Mitsunobu condensation;
DOI:10.1016/S0968-0896(01)00418-7