4-Methoxy-2-methylthio-7-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin

Base Information

• Chemical Name: 4-Methoxy-2-methylthio-7-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin
• CAS No.: 76567-69-6
• Molecular Formula: C₃₄H₃₅N₃O₅S
• Molecular Weight: 597.735
• Mol file: 76567-69-6.mol

Synonyms:4-Methoxy-2-methylthio-7-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin

Chemical Property of 4-Methoxy-2-methylthio-7-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Methoxy-2-methylthio-7-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin

There total 1 articles about 4-Methoxy-2-methylthio-7-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.1%

2,3,5-tri-O-benzyl-D-ribofuranosyl bromide (57378-89-9) + 4-methoxy-2-methylthio-7H-pyrrolo[2,3-d]pyrimidine (29877-76-7) → 4-Methoxy-2-methylthio-7-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin (76567-69-6) + 4-Methoxy-2-methylthio-7-(2,3,5-tri-O-benzyl-α-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin (76567-68-5)

Guidance literature:

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In 1,2-dimethoxyethane; dichloromethane; for 0.25h;

DOI:10.1002/cber.19801131031

Reference yield: 96.3%

4-Methoxy-2-methylthio-7-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin (76567-69-6) → 2-Methylthio-7-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)-4H-pyrrolo<2,3-d>pyrimidin-4-on (76567-71-0)

Guidance literature:

With hydrogenchloride; Santonox R; In 1,4-dioxane; Heating;

DOI:10.1002/cber.19801131031

Reference yield:

4-Methoxy-2-methylthio-7-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin (76567-69-6) → 7-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin-4(3H)-on (76567-72-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 96.3 percent / HCl, 4,4'-thiobis(2-tert-butyl-5-methylphenol) / dioxane / Heating

2: 67.4 percent / Raney-Ni / ethanol; benzene / 4 h / Heating

With hydrogenchloride; Santonox R; nickel; In 1,4-dioxane; ethanol; benzene;

DOI:10.1002/cber.19801131031

upstream raw materials:

2,3,5-tri-O-benzyl-D-ribofuranosyl bromide

4-methoxy-2-methylthio-7H-pyrrolo[2,3-d]pyrimidine

Downstream raw materials:

2-Methylthio-7-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)-4H-pyrrolo<2,3-d>pyrimidin-4-on

7-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin-4(3H)-on

7-deazainosine