methyl 3-[2-({2-[(tert-butoxycarbonyl)(methyl)amino]-4-[(4-methoxybenzyl)oxy]phenyl}amino)-2-oxoethoxy]benzoate

Base Information

Chemical Name:methyl 3-[2-({2-[(tert-butoxycarbonyl)(methyl)amino]-4-[(4-methoxybenzyl)oxy]phenyl}amino)-2-oxoethoxy]benzoate
CAS No.:1242328-94-4
Molecular Formula:C₃₀H₃₄N₂O₈
Molecular Weight:550.609
Hs Code.:

Synonyms:methyl 3-[2-({2-[(tert-butoxycarbonyl)(methyl)amino]-4-[(4-methoxybenzyl)oxy]phenyl}amino)-2-oxoethoxy]benzoate

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Chemical Property of methyl 3-[2-({2-[(tert-butoxycarbonyl)(methyl)amino]-4-[(4-methoxybenzyl)oxy]phenyl}amino)-2-oxoethoxy]benzoate

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Technology Process of methyl 3-[2-({2-[(tert-butoxycarbonyl)(methyl)amino]-4-[(4-methoxybenzyl)oxy]phenyl}amino)-2-oxoethoxy]benzoate

There total 4 articles about methyl 3-[2-({2-[(tert-butoxycarbonyl)(methyl)amino]-4-[(4-methoxybenzyl)oxy]phenyl}amino)-2-oxoethoxy]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1242328-93-3
tert-butyl {2-amino-5-[(4-methoxybenzyl)oxy]phenyl}methylcarbamate

: 113496-11-0
[3-(methoxycarbonyl)phenoxy]acetic acid

: 1242328-94-4
methyl 3-[2-({2-[(tert-butoxycarbonyl)(methyl)amino]-4-[(4-methoxybenzyl)oxy]phenyl}amino)-2-oxoethoxy]benzoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.bmc.2018.09.005

Reference yield:

: 299176-17-3
N-(2-nitro-5-chlorophenyl)-N-methylcarbamic acid t-butyl ester

: 1242328-94-4
methyl 3-[2-({2-[(tert-butoxycarbonyl)(methyl)amino]-4-[(4-methoxybenzyl)oxy]phenyl}amino)-2-oxoethoxy]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

2: iron; ammonium chloride / water; ethanol / 5 h / Reflux

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C / Inert atmosphere

With iron; sodium hydride; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2018.09.005

Reference yield:

: 105-13-5
4-Methoxybenzyl alcohol

: 1242328-94-4
methyl 3-[2-({2-[(tert-butoxycarbonyl)(methyl)amino]-4-[(4-methoxybenzyl)oxy]phenyl}amino)-2-oxoethoxy]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

2: iron; ammonium chloride / water; ethanol / 5 h / Reflux

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C / Inert atmosphere

With iron; sodium hydride; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2018.09.005