1,1-Dimethylethyl 3-hydroxy-1-methyl-5-(phenylmethoxy)-1H-indole-2-carboxylate

Base Information

Chemical Name:1,1-Dimethylethyl 3-hydroxy-1-methyl-5-(phenylmethoxy)-1H-indole-2-carboxylate
CAS No.:167380-82-7
Molecular Formula:C₂₁H₂₃NO₄
Molecular Weight:353.418
Hs Code.:

Synonyms:1,1-Dimethylethyl 3-hydroxy-1-methyl-5-(phenylmethoxy)-1H-indole-2-carboxylate

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Chemical Property of 1,1-Dimethylethyl 3-hydroxy-1-methyl-5-(phenylmethoxy)-1H-indole-2-carboxylate

Chemical Property:

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Technology Process of 1,1-Dimethylethyl 3-hydroxy-1-methyl-5-(phenylmethoxy)-1H-indole-2-carboxylate

There total 5 articles about 1,1-Dimethylethyl 3-hydroxy-1-methyl-5-(phenylmethoxy)-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 121-43-7,63156-11-6
Trimethyl borate

: 167380-81-6
1,1-dimethylethyl 3-bromo-1-methyl-5-(phenylmethoxy)-1H-indole-2-carboxylate

: 167380-82-7
1,1-Dimethylethyl 3-hydroxy-1-methyl-5-(phenylmethoxy)-1H-indole-2-carboxylate

Guidance literature:: With n-butyllithium; dihydrogen peroxide; acetic acid; In tetrahydrofuran; hexane; dichloromethane; water;

Reference yield:

: 61905-91-7
ethyl 1-methyl-5-(phenylmethoxy)-1H-indole-2-carboxylate

: 167380-82-7
1,1-Dimethylethyl 3-hydroxy-1-methyl-5-(phenylmethoxy)-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / pyridine, pyridinium bromide perbromide / 16 h

2: 96 percent / KOH / methanol; H₂O / 5 h / Heating

3: 74 percent / toluene / 2 h / Heating

4: 1.) n-BuLi, 2.) (MeO)3B, 3.) H₂O₂, AcOH

With pyridine; potassium hydroxide; n-butyllithium; Trimethyl borate; dihydrogen peroxide; pyridinium hydrobromide perbromide; acetic acid; In methanol; water; toluene;
DOI:10.1002/jhet.5570330614

Reference yield:

: 167380-79-2
ethyl 3-bromo-1-methyl-5-(phenylmethoxy)-1H-indole-2-carboxylate

: 167380-82-7
1,1-Dimethylethyl 3-hydroxy-1-methyl-5-(phenylmethoxy)-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / KOH / methanol; H₂O / 5 h / Heating

2: 74 percent / toluene / 2 h / Heating

3: 1.) n-BuLi, 2.) (MeO)3B, 3.) H₂O₂, AcOH

With potassium hydroxide; n-butyllithium; Trimethyl borate; dihydrogen peroxide; acetic acid; In methanol; water; toluene;
DOI:10.1002/jhet.5570330614