4,4’-(2,2’-(4,4’-(3-(4-(di-tert-butylsilyl)phenoxy)propane-1,2-diyl)bis(oxy)bis(methylene)bis(1H-1,2,3-triazole-4,1-diyl))bis-(ethane-2,1-diyl))bis(1-(2-methoxyphenyl)piperazine)

Base Information

Chemical Name:4,4’-(2,2’-(4,4’-(3-(4-(di-tert-butylsilyl)phenoxy)propane-1,2-diyl)bis(oxy)bis(methylene)bis(1H-1,2,3-triazole-4,1-diyl))bis-(ethane-2,1-diyl))bis(1-(2-methoxyphenyl)piperazine)
CAS No.:1599422-02-2
Molecular Formula:C₄₉H₇₂N₁₀O₅Si
Molecular Weight:909.26
Hs Code.:

4,4’-(2,2’-(4,4’-(3-(4-(di-tert-butylsilyl)phenoxy)propane-1,2-diyl)bis(oxy)bis(methylene)bis(1H-1,2,3-triazole-4,1-diyl))bis-(ethane-2,1-diyl))bis(1-(2-methoxyphenyl)piperazine)

Synonyms:4,4’-(2,2’-(4,4’-(3-(4-(di-tert-butylsilyl)phenoxy)propane-1,2-diyl)bis(oxy)bis(methylene)bis(1H-1,2,3-triazole-4,1-diyl))bis-(ethane-2,1-diyl))bis(1-(2-methoxyphenyl)piperazine)

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Chemical Property of 4,4’-(2,2’-(4,4’-(3-(4-(di-tert-butylsilyl)phenoxy)propane-1,2-diyl)bis(oxy)bis(methylene)bis(1H-1,2,3-triazole-4,1-diyl))bis-(ethane-2,1-diyl))bis(1-(2-methoxyphenyl)piperazine)

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Technology Process of 4,4’-(2,2’-(4,4’-(3-(4-(di-tert-butylsilyl)phenoxy)propane-1,2-diyl)bis(oxy)bis(methylene)bis(1H-1,2,3-triazole-4,1-diyl))bis-(ethane-2,1-diyl))bis(1-(2-methoxyphenyl)piperazine)

There total 8 articles about 4,4’-(2,2’-(4,4’-(3-(4-(di-tert-butylsilyl)phenoxy)propane-1,2-diyl)bis(oxy)bis(methylene)bis(1H-1,2,3-triazole-4,1-diyl))bis-(ethane-2,1-diyl))bis(1-(2-methoxyphenyl)piperazine) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1599422-01-1
(4-(2,3-bis(prop-2-ynyloxy)propoxy)phenyl)di-tert-butylsilane

: 600709-61-3
1-(2-azidoethyl)-4-(2-methoxyphenyl)piperazine

: 1599422-02-2
4,4’-(2,2’-(4,4’-(3-(4-(di-tert-butylsilyl)phenoxy)propane-1,2-diyl)bis(oxy)bis(methylene)bis(1H-1,2,3-triazole-4,1-diyl))bis-(ethane-2,1-diyl))bis(1-(2-methoxyphenyl)piperazine)

Guidance literature:: With copper(II) sulfate; sodium L-ascorbate; In water; tert-butyl alcohol; at 100 ℃; for 0.25h; Microwave irradiation;
DOI:10.1002/cmdc.201300458

Reference yield:

: 5464-78-8
1-(2-methoxyphenyl)piperazine hydrochloride

: 1599422-02-2
4,4’-(2,2’-(4,4’-(3-(4-(di-tert-butylsilyl)phenoxy)propane-1,2-diyl)bis(oxy)bis(methylene)bis(1H-1,2,3-triazole-4,1-diyl))bis-(ethane-2,1-diyl))bis(1-(2-methoxyphenyl)piperazine)

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 48 h / Reflux

2: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 65 °C / Inert atmosphere

3: sodium L-ascorbate; copper(II) sulfate / tert-butyl alcohol; water / 0.25 h / 100 °C / Microwave irradiation

With diphenyl phosphoryl azide; potassium carbonate; copper(II) sulfate; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium L-ascorbate; In water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1002/cmdc.201300458

Reference yield:

: 1421460-54-9
4-(di-tert-butylsilanyl)phenol

: 1599422-02-2
4,4’-(2,2’-(4,4’-(3-(4-(di-tert-butylsilyl)phenoxy)propane-1,2-diyl)bis(oxy)bis(methylene)bis(1H-1,2,3-triazole-4,1-diyl))bis-(ethane-2,1-diyl))bis(1-(2-methoxyphenyl)piperazine)

Guidance literature:: Multi-step reaction with 4 steps

1.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 48 h / 20 °C / Reflux

2.1: dowex 50WX₈-200 resin / methanol / 48 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 4 h / 0 °C / Reflux

3.2: 15 h / 0 °C / Reflux

4.1: sodium L-ascorbate; copper(II) sulfate / tert-butyl alcohol; water / 0.25 h / 100 °C / Microwave irradiation

With sodium hydride; copper(II) sulfate; sodium L-ascorbate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; water; tert-butyl alcohol;
DOI:10.1002/cmdc.201300458