4-(2-hydroxy-2-propyl)benzaldehyde dimethyl acetal

Base Information

• Chemical Name: 4-(2-hydroxy-2-propyl)benzaldehyde dimethyl acetal
• CAS No.: 142581-73-5
• Molecular Formula: C₁₂H₁₈O₃
• Molecular Weight: 210.273
• Mol file: 142581-73-5.mol

Synonyms:4-(2-hydroxy-2-propyl)benzaldehyde dimethyl acetal

Chemical Property of 4-(2-hydroxy-2-propyl)benzaldehyde dimethyl acetal

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-(2-hydroxy-2-propyl)benzaldehyde dimethyl acetal

There total 1 articles about 4-(2-hydroxy-2-propyl)benzaldehyde dimethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-dimethoxy-1-(4-bromophenyl)methane (24856-58-4) + acetone (67-64-1) → 4-(2-hydroxy-2-propyl)benzaldehyde dimethyl acetal (142581-73-5)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1) THF, hexane, -78 deg C, 20 min, 2) THF, up to RT;

DOI:10.1021/jo00043a043

Reference yield: 94.0%

4-(2-hydroxy-2-propyl)benzaldehyde dimethyl acetal (142581-73-5) → 4-(2-hydroxy-2-propyl)benzene-1-carbaldehyde (81036-81-9)

Guidance literature:

With sulfuric acid; In tetrahydrofuran; for 3h; Ambient temperature;

DOI:10.1021/jo00043a043

Reference yield:

4-(2-hydroxy-2-propyl)benzaldehyde dimethyl acetal (142581-73-5) → 4-(2-hydroxy-2-propyl)benzaldehyde tert-butylimine (142581-74-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / 0.5percent H₂SO₄ in water / tetrahydrofuran / 3 h / Ambient temperature

2: 91 percent / MgSO₄ / CCl₄ / 65 h / Ambient temperature

With sulfuric acid; magnesium sulfate; In tetrahydrofuran; tetrachloromethane;

DOI:10.1021/jo00043a043

upstream raw materials:

1,1-dimethoxy-1-(4-bromophenyl)methane

acetone

Downstream raw materials:

4-(2-hydroxy-2-propyl)benzene-1-carbaldehyde

4-(2-hydroxy-2-propyl)benzaldehyde tert-butylimine

Trifluoro-acetic acid 1-{4-[(Z)-tert-butylimino-methyl]-phenyl}-1-methyl-ethyl ester