149265-10-1

Upstream product

• 1201-91-8 4-(N-methyl-N-hydroxyethylamino)benzaldehyde 
• 98-59-9 p-toluenesulfonyl chloride 
• 104-15-4 toluene-4-sulfonic acid 

Downstream Products

• 1352300-04-9 (Z)-2-[N-methyl-N-(2'-fluoroethyl)-4'-aminostyryl]benzothiazole 
• 1352300-05-0 (E)-2-[N-methyl-N-(2'-fluoroethyl)-4'-aminostyryl]benzothiazole 
• 1352299-97-8 (E)-2-[N-methyl-N-(2'-tosyloxyethyl)-4'-aminostyryl]benzothiazole 
• 1352300-06-1 (Z)-2-[N-methyl-N-(2'-fluoroethyl)-4'-aminostyryl]benzoxazole 
• 1352299-86-5 2-[N-methyl-N-(2'-fluoroethyl)-4'-aminostyryl]benzimidazole 
• 1352300-07-2 (E)-2-[N-methyl-N-(2'-fluoroethyl)-4'-aminostyryl]benzoxazole 
• 1352299-99-0 (E)-2-[N-methyl-N-(2'-tosyloxyethyl)-4'-aminostyryl]benzoxazole 
• 1609645-52-4 4-{[2-(2-hydroxyethoxy)ethyl](methyl)amino}benzaldehyde 
• 1307899-00-8 4-((2-azidoethyl)(methyl)amino)benzaldehyde 

Relevant academic research and scientific papers

A tunable detection range of ion-selective nano-optodes by controlling solvatochromic dye transducer lipophilicity

A range of ionic solvatochromic dye (SD) transducers for use in ion-selective emulsified optical sensors are introduced and characterized. They share the same chromophore group, (E)-4-(4-(dimethylamino)styryl)pyridinium, but vary in their lipophilicities by grafted alkyl or ethoxy groups. The calibration curve is found to shift by a total of 2.7 orders of magnitude with the lipophilicity of the SD.

Chalcone-based fluorescent chemosensors as new tools for detecting Cu2+ ions

The design and full characterization of new fluorescent chemosensors for Cu2+ is herein presented. The structure of the sensors is based on a chalcone backbone as the chromophoric unit, with di-(2-picolyl)amine (DPA) as a receptor moiety. Two s

Synthesis of New Schiff Bases and Assessment of Their in vitro Biological Effects on Acetylcholinesterase and Carbonic Anhydrase Isoenzymes Activities

Abstract: In this study, three new Schiff bases have been synthesized by the reactions of commercially available phenylglycinol, phenylalaninol, and leuicinol with 4-{[2-(4-formylphenoxy)ethyl](methyl)amin}benzaldehyde and characterized by 1H a

With the plaque and A β of the nerve fiber entanglement having affinity to the compound and its preparation method

The invention provides a compound provided with good affinity and tangled with an Abeta plaque and a nerve fiber. The structural general formula (I) of the compound is as shown in the specification, wherein W is a benzo-hexahydric aromatic ring or a hexah

Enhanced electro-optic activity of two novel bichromophores which are synthesized by Cu(I) catalyzed click-reaction

Two novel bichromophores YL1 and YL2 based on traditional aniline chromophore YL were synthesized by Cu(I) catalyzed click-reaction and systematically investigated in this paper. The UV–Vis, electrochemical property, thermal stability and EO activity of t

Highly selective detection of nerve-agent simulants with BODIPY dyes

Two chromo-fluorogenic probes, each based on the boron dipyrromethene core, have been developed for the detection of nerve-agent mimics. These chemosensors display both a color change and a significant enhancement of fluorescence in the presence of diethy

Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes

The formation of proteinaceous aggregates is a pathognomonic hallmark of several neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. To date, the final diagnostic for these diseases can only be achieved by immunostaining of post-mortem brain tissues with the commonly used congo red and Thioflavin T/S amyloid-dyes. The interest in developing amyloid-avid radioprobes to be used for protein aggregates imaging by positron emission tomography has grown substantialy, due to the promise in assisting diagnosis of these disorders. To this purpose, the present work describes the synthesis and characterization of four novel fluorinated styryl benzazole derivatives 1-4 by means of the Wittig reaction, as well as their in vitro evaluation as amyloid-probing agents. All compounds were obtained as mixtures of geometric E and Z isomers, with the preferable formation of the E isomer. Photoisomerization reactions allowed for the maximization of the minor Z isomers. The authentic 1-4E/Z isomers were isolated after purification by column chromatography under dark conditions. Profiting from the fluorescence properties of the different geometric isomers of 1-4, their binding affinities towards amyloid fibrils of insulin, α-synuclein and β-amyloid peptide were also measured. These compounds share similarities with Thioflavin T, interacting specifically with fibrillary species with a red-shift in the excitation wavelengths along with an increase in the fluorescence emission intensity. Apparent binding constants were determined and ranged between 1.22 and 23.96 μM-1. The present data suggest that the novel fluorinated styryl benzazole derivatives may prove useful for the design of 18F-labeled amyloid radioprobes.