N-(6-(6-chloro-5-(4-methoxyphenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide

Base Information

Chemical Name:N-(6-(6-chloro-5-(4-methoxyphenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide
CAS No.:1112980-87-6
Molecular Formula:C₂₁H₁₇ClN₄O₄S₂
Molecular Weight:488.975
Hs Code.:

Synonyms:N-(6-(6-chloro-5-(4-methoxyphenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide

Suppliers and Price of N-(6-(6-chloro-5-(4-methoxyphenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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American Custom Chemicals Corporation
N-[6-[6-CHLORO-5-[[(4-METHOXYPHENYL)SULFONYL]AMINO]-3-PYRIDINYL]-1,3-BENZOTHIAZOL-2-YL]ACETAMIDE 95.00%
5MG
$ 499.52

Total 1 raw suppliers

Chemical Property of N-(6-(6-chloro-5-(4-methoxyphenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide

Chemical Property:

Purity/Quality:: N-[6-[6-CHLORO-5-[[(4-METHOXYPHENYL)SULFONYL]AMINO]-3-PYRIDINYL]-1,3-BENZOTHIAZOL-2-YL]ACETAMIDE 95.00% ^*data from reagent suppliers

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Technology Process of N-(6-(6-chloro-5-(4-methoxyphenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide

There total 4 articles about N-(6-(6-chloro-5-(4-methoxyphenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1112982-81-6
N-(5-bromo-2-chloropyridin-3-yl)-4-methoxybenzenesulfonamide

: 885069-14-7
N-[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-benzothiazol-2-yl]acetamide

: 1112980-87-6
N-(6-(6-chloro-5-(4-methoxyphenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide

Guidance literature:: With sodium carbonate; Pd FibreCat; In 1,4-dioxane; water; at 100 ℃; for 0.2h;

Reference yield:

: 15864-32-1
2-amino-6-bromobenzothiazole

: 1112980-87-6
N-(6-(6-chloro-5-(4-methoxyphenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: dmap / dichloromethane / 0 - 20 °C / Cooling with ice; Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 2.33 h / Inert atmosphere; Heating

3: sodium carbonate / 1,4-dioxane; water / 0.2 h / 100 °C / Inert atmosphere

With dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium carbonate; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; 3: Suzuki coupling;
DOI:10.1021/jm1014605

Reference yield:

: 16628-26-5
N-(6-bromo-1,3-benzothiazol-2-yl)acetamide

: 1112980-87-6
N-(6-(6-chloro-5-(4-methoxyphenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 2.33 h / Inert atmosphere; Heating

2: sodium carbonate / 1,4-dioxane; water / 0.2 h / 100 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium carbonate; In 1,4-dioxane; water; dimethyl sulfoxide; 2: Suzuki coupling;
DOI:10.1021/jm1014605