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16628-26-5

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16628-26-5 Usage

General Description

N-(6-bromobenzo[d]thiazol-2-yl)acetamide is an organic compound with the chemical formula C10H8BrN3OS. It is a derivative of benzo[d]thiazole, which is a heterocyclic compound containing both benzene and thiazole rings. The compound contains a bromine atom and an acetamide group, making it useful for various organic synthesis reactions. It has potential applications in the pharmaceutical and agrochemical industries due to its structural properties and potential biological activities. N-(6-bromobenzo[d]thiazol-2-yl)acetamide may also be used as a building block in the synthesis of other complex organic molecules.

Check Digit Verification of cas no

The CAS Registry Mumber 16628-26-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,6,2 and 8 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 16628-26:
(7*1)+(6*6)+(5*6)+(4*2)+(3*8)+(2*2)+(1*6)=115
115 % 10 = 5
So 16628-26-5 is a valid CAS Registry Number.

16628-26-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(6-Bromo-1,3-benzothiazol-2-yl)acetamide

1.2 Other means of identification

Product number -
Other names 6-Brom-2-acetamino-benzthiazol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:16628-26-5 SDS

16628-26-5Relevant articles and documents

Structure guided optimization of a fragment hit to imidazopyridine inhibitors of PI3K

Pecchi, Sabina,Ni, Zhi-Jie,Han, Wooseok,Smith, Aaron,Lan, Jiong,Burger, Matthew,Merritt, Hanne,Wiesmann, Marion,Chan, John,Kaufman, Susan,Knapp, Mark S.,Janssen, Johanna,Huh, Kay,Voliva, Charles F.

, p. 4652 - 4656 (2013)

PI3 kinases are a family of lipid kinases mediating numerous cell processes such as proliferation, migration and differentiation. The PI3 Kinase pathway is often de-regulated in cancer through PI3Kα overexpression, gene amplification, mutations and PTEN p

HETEROARYL COMPOUNDS AS NECROSIS INHIBITORS, COMPOSITION AND METHOD USING THE SAME

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Paragraph 0082-0084, (2020/07/25)

The present disclosure provides heteroaryl compounds of Formula (I), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to necrosis. Formula (I) i

Medicine with necrocytosis inhibitory activity and application thereof

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Paragraph 0036-0040, (2018/03/24)

The invention provides a medicine with the necrocytosis inhibitory activity. The medicine with the necrocytosis inhibitory activity contains one or two of the following compounds. The invention further provides application of the medicine with the necrocy

Probing the ATP-Binding Pocket of Protein Kinase DYRK1A with Benzothiazole Fragment Molecules

Rothweiler, Ulli,Stensen, Wenche,Brandsdal, Bj?rn Olav,Isaksson, Johan,Leeson, Frederick Alan,Engh, Richard Alan,Svendsen, John S. Mj?en

, p. 9814 - 9824 (2016/11/19)

DYRK1A has emerged as a potential target for therapies of Alzheimer's disease using small molecules. On the basis of the observation of selective DYRK1A inhibition by firefly d-luciferin, we have explored static and dynamic structural properties of fragment sized variants of the benzothiazole scaffold with respect to DYRK1A using X-ray crystallography and NMR techniques. The compounds have excellent ligand efficiencies and show a remarkable diversity of binding modes in dynamic equilibrium. Binding geometries are determined in part by interactions often considered "weak", including "orthogonal multipolar" types represented by, for example, F-CO, sulfur-aromatic, and halogen-aromatic interactions, together with hydrogen bonds that are modulated by variation of electron withdrawing groups. These studies show how the benzothiazole scaffold is highly promising for the development of therapeutic DYRK1A inhibitors. In addition, the subtleties of the binding interactions, including dynamics, show how full structural studies are required to fully interpret the essential physical determinants of binding.

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