6-benzyl-1-(ethoxymethyl)-5-isopropyl-3-(2-oxo-2-phenylethyl)pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:6-benzyl-1-(ethoxymethyl)-5-isopropyl-3-(2-oxo-2-phenylethyl)pyrimidine-2,4(1H,3H)-dione
CAS No.:1026714-30-6
Molecular Formula:C₂₅H₂₈N₂O₄
Molecular Weight:420.508
Hs Code.:

Synonyms:6-benzyl-1-(ethoxymethyl)-5-isopropyl-3-(2-oxo-2-phenylethyl)pyrimidine-2,4(1H,3H)-dione

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Chemical Property of 6-benzyl-1-(ethoxymethyl)-5-isopropyl-3-(2-oxo-2-phenylethyl)pyrimidine-2,4(1H,3H)-dione

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Technology Process of 6-benzyl-1-(ethoxymethyl)-5-isopropyl-3-(2-oxo-2-phenylethyl)pyrimidine-2,4(1H,3H)-dione

There total 7 articles about 6-benzyl-1-(ethoxymethyl)-5-isopropyl-3-(2-oxo-2-phenylethyl)pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 70-11-1
α-bromoacetophenone

: 149950-60-7
Emivirine

: 1026714-30-6
6-benzyl-1-(ethoxymethyl)-5-isopropyl-3-(2-oxo-2-phenylethyl)pyrimidine-2,4(1H,3H)-dione

Guidance literature:: With potassium carbonate; In acetonitrile; for 3h; Reflux; Inert atmosphere;
DOI:10.1021/jm1014378

Reference yield:

: 100-52-7
benzaldehyde

: 1026714-30-6
6-benzyl-1-(ethoxymethyl)-5-isopropyl-3-(2-oxo-2-phenylethyl)pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) LDA / 1.) THF, -70 deg C, 1 h, 2.) THF, -70 deg C, 1 h

2: 35percent H₂O₂, 1N aq. NaOH / 1 h / Ambient temperature

3: pyridine / 12 h / Ambient temperature

4: 85 percent / H₂, aq. AcOH / 10percent Pd/C / dioxane / 15 h / 60 °C / 760 Torr

5: K₂CO₃ / acetonitrile / 2 h / Heating

With pyridine; sodium hydroxide; hydrogen; dihydrogen peroxide; potassium carbonate; acetic acid; lithium diisopropyl amide; palladium on activated charcoal; In 1,4-dioxane; acetonitrile;
DOI:10.1021/jm00015a008

Reference yield:

: 144410-21-9
1-(ethoxymethyl)-5-isopropyl-2-thiouracil

: 1026714-30-6
6-benzyl-1-(ethoxymethyl)-5-isopropyl-3-(2-oxo-2-phenylethyl)pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) LDA / 1.) THF, -70 deg C, 1 h, 2.) THF, -70 deg C, 1 h

2: 35percent H₂O₂, 1N aq. NaOH / 1 h / Ambient temperature

3: pyridine / 12 h / Ambient temperature

4: 85 percent / H₂, aq. AcOH / 10percent Pd/C / dioxane / 15 h / 60 °C / 760 Torr

5: K₂CO₃ / acetonitrile / 2 h / Heating

With pyridine; sodium hydroxide; hydrogen; dihydrogen peroxide; potassium carbonate; acetic acid; lithium diisopropyl amide; palladium on activated charcoal; In 1,4-dioxane; acetonitrile;
DOI:10.1021/jm00015a008