Technology Process of ethyl (3S)-3-[({2-[(4-cyanobenzyl)oxo]-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-yl}carbonyl)amino]-3-phenylpropanoate
There total 7 articles about ethyl (3S)-3-[({2-[(4-cyanobenzyl)oxo]-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-yl}carbonyl)amino]-3-phenylpropanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 100 percent / H2 / Pd/C / ethanol / 20 °C
2: 60 percent / triethylamine / diethyl ether / 5 h / -10 - 20 °C
3: 83 percent / aq. NaHCO3 / 1 h / Heating
4: 17 percent / K2CO3 / acetone / 40 °C
5: 38 percent / potassium fluoride / dimethylformamide / 20 - 60 °C
6: 69 percent / aq. NaOH / ethanol / 20 °C
7: 89 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide; N-methylmorpholine / dimethylformamide / pH 7
With
4-methyl-morpholine; potassium fluoride; sodium hydroxide; hydrogen; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine;
palladium on activated charcoal;
In
diethyl ether; ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm048984g
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 96 percent / sulphuric acid / 2 h / Heating
2: 100 percent / H2 / Pd/C / ethanol / 20 °C
3: 60 percent / triethylamine / diethyl ether / 5 h / -10 - 20 °C
4: 83 percent / aq. NaHCO3 / 1 h / Heating
5: 17 percent / K2CO3 / acetone / 40 °C
6: 38 percent / potassium fluoride / dimethylformamide / 20 - 60 °C
7: 69 percent / aq. NaOH / ethanol / 20 °C
8: 89 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide; N-methylmorpholine / dimethylformamide / pH 7
With
4-methyl-morpholine; potassium fluoride; sodium hydroxide; sulfuric acid; hydrogen; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine;
palladium on activated charcoal;
In
diethyl ether; ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm048984g
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 17 percent / K2CO3 / acetone / 40 °C
2: 38 percent / potassium fluoride / dimethylformamide / 20 - 60 °C
3: 69 percent / aq. NaOH / ethanol / 20 °C
4: 89 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide; N-methylmorpholine / dimethylformamide / pH 7
With
4-methyl-morpholine; potassium fluoride; sodium hydroxide; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;
In
ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm048984g
