4-(3-ETHOXYPHENYL)-4-OXOBUTYRIC ACID

Base Information

• Chemical Name: 4-(3-ETHOXYPHENYL)-4-OXOBUTYRIC ACID
• CAS No.: 905592-33-8
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.241
• Mol file: 905592-33-8.mol

Synonyms:4-(3-ethoxyphenyl)-4-oxobutanoic acid

Chemical Property of 4-(3-ETHOXYPHENYL)-4-OXOBUTYRIC ACID

Chemical Property:

• Vapor Pressure: 3.95E-07mmHg at 25°C
• Boiling Point: 400.4±25.0 °C(Predicted)
• PKA: 4.52±0.17(Predicted)
• Density: 1.175±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

4-(3-ETHOXYPHENYL)-4-OXOBUTYRICACID ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-ETHOXYPHENYL)-4-OXOBUTYRIC ACID

There total 3 articles about 4-(3-ETHOXYPHENYL)-4-OXOBUTYRIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

succinic acid anhydride (108-30-5) + Phenetole (103-73-1) → 4-(3-ethoxyphenyl)-4-oxobutanoic acid (905592-33-8)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at 0 - 20 ℃; for 8h; Inert atmosphere;

DOI:10.1002/adsc.201801186

Reference yield:

N-(5-benzyl-4-phenyl-1,3-thiazol-2-yl)-4-(4-ethoxyphenyl)-4-oxobutanamide (905590-59-2) + 4-(3-ethoxyphenyl)-4-oxobutanoic acid ethyl etser (905592-32-7) → 4-(3-ethoxyphenyl)-4-oxobutanoic acid (905592-33-8)

Guidance literature:

With sodium hydroxide; In ethanol;

Reference yield:

4-(3-ethoxyphenyl)-4-oxobutanoic acid ethyl etser (905592-32-7) → 4-(3-ethoxyphenyl)-4-oxobutanoic acid (905592-33-8)

Guidance literature:

4-(3-ethoxyphenyl)-4-oxobutanoic acid ethyl etser; With water; sodium hydroxide; In ethanol; for 12h;

With hydrogenchloride; In ethanol; water;

upstream raw materials:

4-(3-ethoxyphenyl)-4-oxobutanoic acid ethyl etser

N-(5-benzyl-4-phenyl-1,3-thiazol-2-yl)-4-(4-ethoxyphenyl)-4-oxobutanamide

succinic acid anhydride

Phenetole

Downstream raw materials:

N-(5-benzyl-4-phenyl-1,3-thiazol-2-yl)-4-(3-ethoxyphenyl)-4-oxobutanamide

4-(3-ethoxyphenyl)-4,4-dimethoxybutanoic acid potassium salt